(Maridebart)Biosimilar-Reference-Antibody-GS40421

货号：GS40421

Maridebart (AMG 133) is an investigational antibody-peptide conjugate designed for the treatment of obesity and type 2 diabetes. Its unique structure consists of a monoclonal antibody scaffold conjugated to engineered peptide modules that confer dual agonism/antagonism: it acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist. This dual mechanism aims to amplify GLP-1-mediated appetite suppression and glycemic control while simultaneously blocking GIP signaling, which is hypothesized to further enhance weight loss. By leveraging the long half-life of an antibody format, it is developed as a once-monthly subcutaneous injection to improve patient adherence.