(Nolavetbart)Biosimilar Reference Antibody-GS40480 新品

货号：GS40480

Nolavetbart is a caninized IgG2‑kappa monoclonal antibody specifically developed for veterinary use. It targets the canine interleukin‑31 receptor alpha (IL‑31RA), a key component of the receptor for the pruritic (itch‑inducing) cytokine IL‑31. As an IgG2 isotype, it is engineered to minimize effector functions (e.g., reduced risk of antibody‑dependent cellular cytotoxicity) while focusing on receptor blockade. By binding to canine IL‑31RA, nolavetbart prevents IL‑31 from activating its receptor, thereby inhibiting the downstream signaling pathway that triggers pruritus and inflammation.