Product Name：AUNP-12
CAS No.：1353563-85-5；1353564-66-5
Synonyms：抑制剂多肽AUNP-12
Catalog No.：217P698
Brand：Typeptide Biotech（肽研生物）
Description：AUNP-12是一种新型的免疫检查点调节剂，是PD-1信号通路的抑制剂多肽，序列中含有29个氨基酸，肽链中具有分支结构，赖氨酸侧链接上一个7个氨基酸的支链。在表达hPDL2的HEK293细胞中，对淋巴细胞增殖和效应功能方面对PD-L1和PD-L2表现出等效的拮抗作用。EC50为0.72 nM；在表达hPDL1的MDA-MB231细胞中，PBMC增殖试验中，EC50为0.41 nM。
AUNP-12 is a novel immune checkpoint regulator and an inhibitor peptide of the PD-1 signaling pathway. It contains a sequence of 29 amino acids and has a branched structure in the peptide chain, with a 7-amino acid side chain linked to the lysine side. In HEK293 cells expressing hPDL2, equivalent antagonistic effects were observed on PD-L1 and PD-L2 in terms of lymphocyte proliferation and effector function. The EC50 was 0.72 nM; in MDA-MB231 cells expressing hPDL1, the EC50 was 0.41 nM in the PBMC proliferation assay.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | SNTSESFK（SNTSESF）FRVTQLAPKAQIKE-NH2 |
Sequence(3-letter code) | H-Ser-Asn-Thr-Ser-Glu-Ser-Phe-Lys(Ser-Asn-Thr-Ser-Glu-Ser-Phe)-Phe-Arg-Val-Thr-Gln-Leu-Ala-Pro-Lys-Ala-Gln-Ile-Lys-Glu-NH2 |
Peptide Structure | 
|
Molecular Formula | C142H226N40O48 |
Molecular Weight | 3261.54 |
订购联系方式：
南京肽研生物生物科技有限公司
手机号：19961912513(微信同号)
QQ: 2178255659
邮箱：sales@typeptide.com
联系人：顾经理
申明：本产品仅供科研使用，不得用于人体。
关键字： AUNP-12;抑制剂多肽AUNP-12;1353563-85-5;1353564-66-5;多肽;
肽研生物坐落于国家级新区南京江北新区新材料产业园，是一家专业从事多肽产 品的研发、生产和销售以及多肽技术转让的高新技术企业。公司秉持“诚信、严 谨、务实”的匠人精神，持续投入研发，不断创新，致力于为科研工作者提供丰 富全面的多肽修饰类型和优质的产品。