中文名称RMC-6236中文同义词RAS-IN-2;化合物RMC-6236;(1S,2S)-N-[(2R,14S,18S)-1-乙基-18,19,20,21-四氢-2-[2-[(1S)-1-甲氧基乙基]-5-(4-甲基-1-哌嗪基)-3-吡啶基]-25,25-二甲基-15,22-二氧代-17H-5,3-([4,2]-ENDO-噻唑丙烷并[1,3]-ENDO-2-哒嗪基甲氧基丙烷)-1H-吲哚-14-基]-2-甲基环丙烷甲酰胺;泛KRAS抑制剂;(1S,2S)-N-[(2R,14S,18S)-1-乙基-18,19,20,21-四氢-2-[2-[(1S)-1-甲氧基乙基]-5-(4-甲基-1-哌嗪基)-3-吡啶基]-25,25-二甲基-15,22-二氧代-17H-5,3-([4,2]-ENDO-噻唑丙烷并[1,3]-ENDO-2-哒嗪基甲氧基丙烷)-1H-吲哚-;RMC-6236RASONMULTI抑制剂;RMC-6236(Daraxonrasib);RMC-6236酶抑制剂英文名称RMC6236英文同义词RMC6236;(Z)-N-(11-ethyl-12-(2-(1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)-2-methylcyclopropane-1-carboxamide;(1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide,RMC-6236;(1S,2S)-N-[(2R,14S,18S)-1-Ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-cyclopropanecarboxamide;RMC-6236RASONMULTI;Cyclopropanecarboxamide,N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-25,25-dimethyl-15,22-dioxo-17H-5,3-([4,2]-endo-thiazolopropano[1,3]-endo-pyridazinomethanoxypropano)-1H-indol-14-yl]-2-methyl-,(1S,2S)-;"Cyclopropanecarboxamide,N-[(2R,14S,18S)-1-ethyl-18,19,20,21-tetrahydro-2-[2-[(1S)-1-methoxyethyl]-5-(4-methyl-1-piperazinyl)-3-pyridinyl]-2";(1S,2S)-N-((63S,4S,Z)-11-ethyl-12-(2-((S)-1-methoxyethyl)-5-(4-methylpiperazin-1-yl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-thiazola-1(5,3)-indola-6(1,3)-pyCAS号2765081-21-6分子式C44H58N8O5S分子量811.05
RMC-6236性质密度1.37±0.1g/cm3(Predicted)溶解度DMSO:Sparinglysoluble:1-10mg/mlEthChemicalbookanol:Sparinglysoluble:1-10mg/ml酸度系数(pKa)14.56±0.40(Predicted)形态固体颜色白色至米白色
关键字： 2765081-21-6;RMC-6236;
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