11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Dermal: No data available
Skin corrosion/irritation
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Evidence of a carcinogenic effect.
Reproductive toxicity
Suspected of damaging the unborn child.
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
Mixture may cause drowsiness or dizziness.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Dichloromethane is metabolized in the body producing carbon monoxide which increases and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity of the blood., Acts as a simple asphyxiant by displacing air., anesthetic effects, Breathing difficulties, Headache, Dizziness, Prolonged or repeated contact with skin may cause:, defatting, Dermatitis, Contact with eyes can cause:, Redness, Blurred vision, Provokes tears.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components Dichloromethane
Acute toxicity
LD50 Oral - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Mouse - 4 h - 86 mg/l - vapor
Remarks: (ECHA)
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Irritations - 4 h (OECD Test Guideline 404)
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing properties of the product.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation
Remarks: (ECHA)
Remarks: Risk of corneal clouding.
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Result: positive
Test Type: Ames test
Test system: Salmonella typhimurium
Result: positive
Method: OECD Test Guideline 474
Species: Mouse - male and female - Bone marrow
Result: negative
Carcinogenicity
Suspected of causing cancer.
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
n-Hexane Acute toxicity
LD50 Oral - Rat - male and female - 16,000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - 4 h - 172 mg/l - vapor
Remarks: (RTECS)
LD50 Dermal - Rabbit - male - > 2,000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Skin irritation - 24 h (OECD Test Guideline 404)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 72 h (OECD Test Guideline 405)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Method: OECD Test Guideline 478
Species: Mouse - male
Result: negative
Method: OECD Test Guideline 475
Species: Rat - male and female - Bone marrow
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging fertility.
Specific target organ toxicity - single exposure
May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Inhalation - Causes damage to organs through prolonged or repeated exposure.
- Nervous system
Aspiration hazard
Aspiration may cause pulmonary edema and pneumonitis.