11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 2,140 mg/kg
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Remarks: (RTECS)
The value is given in analogy to the following substances: biphenyl
Symptoms: mucosal irritations, Cough, Shortness of breath, Inhalation may lead to the formation of oedemas in the respiratory tract., Possible damages:, damage of respiratory tract
LD50 Dermal - Rabbit - > 5,010 mg/kg
Remarks: (RTECS)
The value is given in analogy to the following substances: biphenyl
Skin corrosion/irritation
Skin - Rabbit
Result: Severe irritations - 24 h (Draize Test)
Remarks: The value is given in analogy to the following substances: biphenyl
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Serious eye damage/eye irritation
Remarks: Causes serious eye irritation.
Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: biphenyl
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: biphenyl
Germ cell mutagenicity
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Metabolic activation: without metabolic activation
Method: OECD Test Guideline 476
Result: positive
Remarks: The value is given in analogy to the following substances: biphenyl
Test Type: Micronucleus test
Species: Mouse
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Remarks: The value is given in analogy to the following substances: biphenyl
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation. - Respiratory system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: biphenyl
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Liver injury may occur., Gastrointestinal disturbance
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
The value is given in analogy to the following substances: biphenyl
After uptake:
The value is given in analogy to the following substances: biphenyl muscular weakness
Drowsiness
Diarrhea ataxia (impaired locomotor coordination)
The value is given in analogy to the following substances: biphenyl
After long-term exposure to the chemical:
The value is given in analogy to the following substances: biphenyl
Damage to:
The value is given in analogy to the following substances: biphenyl
Liver
Kidney
Cardiac
The value is given in analogy to the following substances: biphenyl
Other dangerous properties can not be excluded.
The value is given in analogy to the following substances: biphenyl
Handle in accordance with good industrial hygiene and safety practice.
The value is given in analogy to the following substances: biphenyl