Chemical Safety Data Sheet MSDS / SDS
TOLUENE (RING-D5)
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: TOLUENE (RING-D5)
- CBnumber: CB3427633
- CAS: 1603-99-2
- Synonyms: Toluene-d5 ;methylbenzene-d5
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P331 Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P273 Avoid release to the environment.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P201 Obtain special instructions before use.
Hazard statements
H412 Harmful to aquatic life with long lasting effects
H373 May cause damage to organs through prolonged or repeated exposure
H336 May cause drowsiness or dizziness
H315 Causes skin irritation
H304 May be fatal if swallowed and enters airways
H225 Highly Flammable liquid and vapour
Substance
- Product name: TOLUENE (RING-D5)
- Synonyms: Toluene-d5 ;methylbenzene-d5
- CAS: 1603-99-2
- MF: C7H8
- MW: 92.14
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.
If swallowed
After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary failure possible after aspiration of vomit. Call a physician immediately.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaFoam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains. Risk of explosion.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.
Chemizorb®). Dispose of properly. Clean up affected area.
Chemizorb®). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Advice on protection against fire and explosion
Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsKeep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.
Store under inert gas. hygroscopic
Storage class
Store under inert gas. hygroscopic
Storage class (TRGS 510): 3: Flammable liquids
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['Toluene-\n2,3,4,5,6-d5', '1603-99-2', 'PC-TWA', '50 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] | ['', 'Remarks', 'Skin', None, None] | ['', '', 'PC-STEL', '100 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] | ['', '', 'Skin', None, None] |
|---|
| ['Component', 'CAS-No.', 'Parameters', 'Value', 'Biological\nspecimen', 'Basis'] | ['', '1603-99-2', 'hippuric\nacid', '1mol/mo\nl\ncreatinin\ne', 'Urine', 'China. Biological\nOccupational\nExposure Indices'] | ['', 'Remarks', 'End of workshift (after exposure has ended)', None, None, None] | ['', '', 'hippuric\nacid', '1.5g/g\ncreatinin\ne', 'Urine', 'China. Biological\nOccupational\nExposure Indices'] | ['', '', 'End of workshift (after exposure has ended)', None, None, None] | ['', '', 'hippuric\nacid', '11Millim\noles per\nliter', 'Urine', 'China. Biological\nOccupational\nExposure Indices'] | ['', '', 'End of workshift (after exposure has ended)', None, None, None] | ['', '', 'hippuric\nacid', '2 g/l', 'Urine', 'China. Biological\nOccupational\nExposure Indices'] | ['', '', 'End of workshift (after exposure has ended)', None, None, None] | ['', '', 'toluene', '20mg/m\n³', 'end exhaled air', 'China. Biological\nOccupational\nExposure Indices'] | ['', '', 'End of workshift (15-30 min after exposure has ended)', None, None, None] | ['', '', 'toluene', '5mg/m³', 'end exhaled air', 'China. Biological\nOccupational\nExposure Indices'] | ['', '', 'Prior to shift', None, None, None] |
|---|
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Internet: www.kcl.de).
Full contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Body Protection
Flame retardant antistatic protective clothing.
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains. Risk of explosion.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorColourless
- c) OdorNo data available
- d) Melting point/freezing pointMelting point/range: -93 °C - lit.
- e) Initial boiling point and boiling range110 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsUpper explosion limit: 7 %(V)
Lower explosion limit: 1.2 %(V) - h) Flash point4 °C
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressure29.1 hPa at 20.0 °C
- p) Density0.912 g/mL at 25 °C
- Relative density0.912 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- SolubilityChloroform (Sparingly), Methanol (Slightly)
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Risk of explosion with: fuming sulfuric acid
Nitric acid silver perchlorates nitrogen dioxide nonmetallic halides halogen-halogen compounds uranium hexafluoride organic nitro compounds
Violent reactions possible with:
Strong acids
Strong oxidizing agents sulfur with
Heat.
Nitric acid silver perchlorates nitrogen dioxide nonmetallic halides halogen-halogen compounds uranium hexafluoride organic nitro compounds
Violent reactions possible with:
Strong acids
Strong oxidizing agents sulfur with
Heat.
10.3 Conditions to avoid
Warming.
Warming.
Warming.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male - 5,580 mg/kg (Directive 67/548/EEC, Annex V, B.1.)
LC50 Inhalation - Rat - male - 4 h - 25.7 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - > 5,000 mg/kg
Remarks: (ECHA)
Skin corrosion/irritation
LC50 Inhalation - Rat - male - 4 h - 25.7 mg/l - vapor (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male - > 5,000 mg/kg
Remarks: (ECHA)
Skin - Rabbit
Result: irritating - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)
Serious eye damage/eye irritation
Result: irritating - 4 h (Regulation (EC) No. 440/2008, Annex, B.4)
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Result: No eye irritation (OECD Test Guideline 405)
Maximization Test - Guinea pig
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Germ cell mutagenicity
Result: negative (Regulation (EC) No. 440/2008, Annex, B.6)
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: Regulation (EC) No. 440/2008, Annex, B.13/14 (Ames test)
Result: negative
Test Type: Chromosome aberration test
Species: Rat
Cell type: Bone marrow
Application Route: Intraperitoneal
Result: negative
Remarks: (ECHA)
Carcinogenicity
Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: Regulation (EC) No. 440/2008, Annex, B.13/14 (Ames test)
Result: negative
Test Type: Chromosome aberration test
Species: Rat
Cell type: Bone marrow
Application Route: Intraperitoneal
Result: negative
Remarks: (ECHA)
Classified based on available data. For more details, see section 2
Reproductive toxicity
Suspected of damaging the unborn child.
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Specific target organ toxicity - repeated exposure
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Inhalation - May cause damage to organs through prolonged or repeated exposure.
- Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration hazard
- Central nervous system
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
Aspiration may cause pulmonary edema and pneumonitis.
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - 13 Weeks - NOAEL (No observed adverse effect level) - 625 mg/kg - LOAEL (Lowest observed adverse effect level) - 1,250 mg/kg
Drowsiness, irritant effects, Dizziness, Convulsions, Headache, Nausea, Vomiting,
Circulatory collapse, somnolence, inebriation, Unconsciousness, respiratory arrest, CNS disorders, respiratory paralysis, death
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Drowsiness, irritant effects, Dizziness, Convulsions, Headache, Nausea, Vomiting,
Circulatory collapse, somnolence, inebriation, Unconsciousness, respiratory arrest, CNS disorders, respiratory paralysis, death
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12.1 Toxicity
Toxicity to fish flow-through test LC50 - Oncorhynchus kisutch (coho salmon) - 5.5 mg/l - 96 h
Remarks: (ECHA)
Toxicity to daphnia EC50 - Ceriodaphnia dubia (water flea) - 3.78 mg/l - 48 h and other aquatic (US-EPA) invertebrates
Toxicity to bacteria static test EC50 - Bacteria - 84 mg/l - 24 h
Remarks: (ECHA)
Toxicity to flow-through test NOEC - Oncorhynchus kisutch (coho salmon) - 1.39 fish(Chronic toxicity) mg/l - 40 d
Remarks: (ECHA)
Toxicity to daphnia NOEC - Ceriodaphnia dubia (water flea) - 0.74 mg/l - 7 d and other aquatic (US-EPA) invertebrates(Chronic toxicity)
Remarks: (ECHA)
Toxicity to daphnia EC50 - Ceriodaphnia dubia (water flea) - 3.78 mg/l - 48 h and other aquatic (US-EPA) invertebrates
Toxicity to bacteria static test EC50 - Bacteria - 84 mg/l - 24 h
Remarks: (ECHA)
Toxicity to flow-through test NOEC - Oncorhynchus kisutch (coho salmon) - 1.39 fish(Chronic toxicity) mg/l - 40 d
Remarks: (ECHA)
Toxicity to daphnia NOEC - Ceriodaphnia dubia (water flea) - 0.74 mg/l - 7 d and other aquatic (US-EPA) invertebrates(Chronic toxicity)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 20 d
Result: 86 % - Readily biodegradable.
Remarks: (IUCLID)
Result: 86 % - Readily biodegradable.
Remarks: (IUCLID)
12.3 Bioaccumulative potential
Bioaccumulation Leuciscus idus (Golden orfe) - 3 d - 0.05 mg/l(Toluene-2,3,4,5,6-d5)
Bioconcentration factor (BCF): 90
Bioconcentration factor (BCF): 90
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 1294
IMDG: 1294
IATA-DGR: 1294
IMDG: 1294
IATA-DGR: 1294
14.2 UN proper shipping name
ADR/RID: TOLUENE
IMDG: TOLUENE
IATA-DGR: Toluene
IMDG: TOLUENE
IATA-DGR: Toluene
14.3 Transport hazard class(es)
ADR/RID: 3
IMDG: 3
IATA-DGR: 3
IMDG: 3
IATA-DGR: 3
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222220816
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222220816
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.