11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Acute toxicity estimate Oral - 378,79 mg/kg (Calculation method)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Symptoms: Possible symptoms:, mucosal irritations
Acute toxicity estimate Dermal - > 2.000 mg/kg (Calculation method)
Skin corrosion/irritation
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye damage.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May harm the unborn child.
May impair fertility.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Nausea, Headache, Vomiting, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components 2-Methyltetrahydrofuran
Acute toxicity
LD50 Oral - Rat - female - > 300 - 2.000 mg/kg (OECD Test Guideline 420)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - In vitro study
Result: irritating - 15 min (OECD Test Guideline 439)
Serious eye damage/eye irritation
Eyes - In vitro study
Result: Corrosive - 10 min (OECD Test Guideline 437)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Acute oral toxicity - Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract., Risk of aspiration upon vomiting., Aspiration may cause pulmonary edema and pneumonitis.
Acute inhalation toxicity - Possible damages:, mucosal irritations
Specific target organ toxicity - repeated exposure Aspiration hazard
Classified based on available data. For more details, see section 2
borane-dimethyl sulfide (1:1) Acute toxicity
Oral: No data available
Inhalation: Irritating to respiratory system.
LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Remarks: No data available
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Causes serious eye damage. - 24 h
Remarks: (ECHA)
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
May damage the unborn child.
May damage fertility.
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2