11.1 Information on toxicological effects
Mixture Acute toxicity
Acute toxicity estimate Oral - 117,38 mg/kg (Calculation method)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Acute toxicity estimate Inhalation - 4 h - 0,3981 mg/l - vapor(Calculation method)
Symptoms: Possible symptoms:, mucosal irritations
Acute toxicity estimate Dermal - 239,13 mg/kg (Calculation method)
Skin corrosion/irritation
Remarks: Mixture causes skin irritation.
Serious eye damage/eye irritation
Remarks: Mixture causes serious eye irritation.
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Other dangerous properties can not be excluded.
This substance should be handled with particular care.
Handle in accordance with good industrial hygiene and safety practice.
Components boron hydride-pyridine (1:1)
Acute toxicity
LD50 Oral - Rat - 95,4 mg/kg
Remarks: (External MSDS)
LC50 Inhalation - Rat - 4 h - 0,32 mg/l - vapor
Remarks: (External MSDS)
LD50 Dermal - Guinea pig - 200 mg/kg
Remarks: (External MSDS)
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Pyridine
Acute toxicity
LD50 Oral - Rat - 1.500 mg/kg
Remarks: (ECHA)
Symptoms: Vomiting, Nausea
Acute toxicity estimate Oral - 1.500 mg/kg (Calculation method)
LC50 Inhalation - Rat - male - 4 h - 17,1 mg/l - vapor (US-EPA)
Symptoms: mucosal irritations, Cough, Shortness of breath
Acute toxicity estimate Inhalation - 17,1 mg/l - vapor (Calculation method)
LD50 Dermal - Rabbit - > 1.000 - 2.000 mg/kg (OECD Test Guideline 402)
Acute toxicity estimate Dermal - 1.000,1 mg/kg (Calculation method)
Skin corrosion/irritation
Skin - Rabbit
Result: Mild skin irritation - 24 h (Draize Test)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Irritating to eyes. - 24 h
Remarks: (ECHA)
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Result: negative
Method: OECD Test Guideline 475
Species: Mouse - male - Bone marrow
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Acute oral toxicity - Vomiting, Nausea
Acute inhalation toxicity - mucosal irritations, Cough, Shortness of breath
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2