Chemical Safety Data Sheet MSDS / SDS
ETHYLENE GLYCOL-(OD)2
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: ETHYLENE GLYCOL-(OD)2
- CBnumber: CB9193565
- CAS: 2219-52-5
- Synonyms: 1,2-ethanediol-d2 ;ETHYLENE GLYCOL-D2
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P501 Dispose of contents/container to..…
P330 Rinse mouth.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
Hazard statements
H302 Harmful if swallowed
Substance
- Product name: ETHYLENE GLYCOL-(OD)2
- Synonyms: 1,2-ethanediol-d2 ;ETHYLENE GLYCOL-D2
- CAS: 2219-52-5
- MF: C2H4D2O2
- MW: 64.08
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaWater Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Prevent fire extinguishing water from contaminating surface water or the ground water system.
Prevent fire extinguishing water from contaminating surface water or the ground water system.
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed.
Storage class
Storage class (TRGS 510): 10: Combustible liquids
8.1 Control parameters
Ingredients with workplace control parameters| ['Component', 'CAS-No.', 'Value', 'Control\nparameters', 'Basis'] | ['1,2-Ethanediol-d2', '2219-52-5', 'PC-TWA', '20 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] | ['', '', 'PC-STEL', '40 mg/m3', 'Occupational exposure limits for\nhazardous agents in the\nworkplace - Chemical\nhazardous agents.'] |
|---|
8.2 Exposure controls
Appropriate engineering controlsChange contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
Body Protection
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.11 mm
Break through time: 480 min
Material tested:KCL 741 L
protective clothing
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) ColorColourless
- c) OdorNo data available
- d) Melting point/freezing pointMelting point/range: -13 °C - lit.
- e) Initial boiling point and boiling range196 - 198 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point110 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.148 g/mL at 25 °C 1.148 g/cm3 at 25 °C
- Relative density1.148 g/mL at 25 °C
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- SolubilityWater (Slightly)
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Stable
Avoid moisture.
Stable
Avoid moisture.
10.2 Possibility of hazardous reactions
Risk of explosion with:
Aluminum perchloric acid
Risk of ignition or formation of inflammable gases or vapours with: chromyl chloride
Strong oxidizing agents chlorates
Peroxides potassium permanganate
Exothermic reaction with: chlorosulfonic acid
Sodium hydroxide fuming sulfuric acid sulfuric acid
Aluminum perchloric acid
Risk of ignition or formation of inflammable gases or vapours with: chromyl chloride
Strong oxidizing agents chlorates
Peroxides potassium permanganate
Exothermic reaction with: chlorosulfonic acid
Sodium hydroxide fuming sulfuric acid sulfuric acid
10.3 Conditions to avoid
Strong heating.
10.4 Incompatible materials
No data available
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityAcute toxicity estimate Oral - 500.1 mg/kg (Expert judgment)
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: ethylene glycol
LC50 Inhalation - Rat - male and female - 6 h - > 2.5 mg/l - aerosol
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
LD50 Dermal - Mouse - male and female - > 3,500 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Skin corrosion/irritation
Remarks: Classified according to Regulation (EU) 1272/2008, Annex VI (Table 3.1/3.2)
The value is given in analogy to the following substances: ethylene glycol
LC50 Inhalation - Rat - male and female - 6 h - > 2.5 mg/l - aerosol
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
LD50 Dermal - Mouse - male and female - > 3,500 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Skin - Rabbit
Result: No skin irritation - 20 h
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Serious eye damage/eye irritation
Result: No skin irritation - 20 h
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Eyes - Rabbit
Result: No eye irritation - 24 h
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Respiratory or skin sensitization
Result: No eye irritation - 24 h
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Maximization Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Germ cell mutagenicity
Result: negative (OECD Test Guideline 406)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: ethylene glycolTest
Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: ethylene glycol
Test Type: dominant lethal test
Species: Rat
Application Route: Oral
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
Carcinogenicity
Test system: Escherichia coli/Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: ethylene glycolTest
Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: ethylene glycol
Test Type: dominant lethal test
Species: Rat
Application Route: Oral
Result: negative
Remarks: (ECHA)
The value is given in analogy to the following substances: ethylene glycol
This product is or contains a component that is probably not carcinogenic based on its
IARC, ACGIH, NTP, or EPA classification.
Reproductive toxicity
IARC, ACGIH, NTP, or EPA classification.
Laboratory experiments have shown teratogenic effects.
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Specific target organ toxicity - single exposure
Overexposure may cause reproductive disorder(s) based on tests with laboratory animals.
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Oral - May cause damage to organs through prolonged or repeated exposure.
- Kidney
Remarks: The value is given in analogy to the following substances: ethylene glycol
Aspiration hazard
- Kidney
Remarks: The value is given in analogy to the following substances: ethylene glycol
Classified based on available data. For more details, see section 2
11.2 Additional Information
When ingested early symptoms mimic alcohol inebriation and are followed by nausea, vomiting, abdominal pain, weakness, muscle tenderness, respiratory failure, convulsions, cardiovascular collapse, pulmonary edema, hypocalcemic tetany, and severe metabolic acidosis. Without treatment, death may occur in 8 to 24 hours. Victims who survive the initial toxicity period usually develop renal failure along with brain and liver damage.,
Exposure to and/or consumption of alcohol may increase toxic effects.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption: agitation
CNS disorders
Systemic effects:
After a latency period:
Tiredness ataxia (impaired locomotor coordination)
Unconsciousness
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Exposure to and/or consumption of alcohol may increase toxic effects.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
After absorption: agitation
CNS disorders
Systemic effects:
After a latency period:
Tiredness ataxia (impaired locomotor coordination)
Unconsciousness
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
12.1 Toxicity
Toxicity to fish static test LC50 - Pimephales promelas (fathead minnow) - 72,860 mg/l - 96 h (US-EPA)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances: ethylene glycol
Toxicity to algae static test NOEC - Pseudokirchneriella subcapitata (green algae) - > 100 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Toxicity to flow-through test LC50 - Menidia peninsulae (tidewater silverside) - fish(Chronic toxicity) > 1,500 mg/l - 28 d
Remarks: (ECHA)
The value is given in analogy to the following substances: triethylene glycol
Toxicity to daphnia semi-static test NOEC - Ceriodaphnia dubia (water flea) - 8,590 mg/l and other aquatic - 7 d invertebrates(Chronic (US-EPA) toxicity) Remarks: The value is given in analogy to the following substances: ethylene glycol
Remarks: The value is given in analogy to the following substances: ethylene glycol
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates Remarks: The value is given in analogy to the following substances: ethylene glycol
Toxicity to algae static test NOEC - Pseudokirchneriella subcapitata (green algae) - > 100 mg/l - 72 h (OECD Test Guideline 201)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Toxicity to flow-through test LC50 - Menidia peninsulae (tidewater silverside) - fish(Chronic toxicity) > 1,500 mg/l - 28 d
Remarks: (ECHA)
The value is given in analogy to the following substances: triethylene glycol
Toxicity to daphnia semi-static test NOEC - Ceriodaphnia dubia (water flea) - 8,590 mg/l and other aquatic - 7 d invertebrates(Chronic (US-EPA) toxicity) Remarks: The value is given in analogy to the following substances: ethylene glycol
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 10 d
Result: 90 - 100 % - Readily biodegradable.
(OECD Test Guideline 301A)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Biochemical Oxygen 780 mg/g
Demand (BOD) Remarks: (IUCLID)
Chemical Oxygen 1,190 mg/g
Demand (COD) Remarks: (IUCLID)
Theoretical oxygen 1,290 mg/g demand Remarks: (IUCLID)
Ratio BOD/ThBOD 60 %
Remarks: (IUCLID)
Result: 90 - 100 % - Readily biodegradable.
(OECD Test Guideline 301A)
Remarks: The value is given in analogy to the following substances: ethylene glycol
Biochemical Oxygen 780 mg/g
Demand (BOD) Remarks: (IUCLID)
Chemical Oxygen 1,190 mg/g
Demand (COD) Remarks: (IUCLID)
Theoretical oxygen 1,290 mg/g demand Remarks: (IUCLID)
Ratio BOD/ThBOD 60 %
Remarks: (IUCLID)
12.3 Bioaccumulative potential
Does not bioaccumulate.
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
IMDG: Not dangerous goods
IATA-DGR: Not dangerous goods
14.3 Transport hazard class(es)
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.4 Packaging group
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
14.7 Incompatible materials
Further information: Not classified as dangerous in the meaning of transport regulations.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Law on the Prevention and Control of Occupational Diseases
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222223391
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Law on the Prevention and Control of Occupational Diseases
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number : B1A222223391
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.