11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - female - 27,200 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: glycerine
LC50 Inhalation - Rat - male and female - 4 h - > 5,850 mg/l - aerosol
Remarks: (ECHA)
The value is given in analogy to the following substances: glycerine
LD50 Dermal - Guinea pig - male and female - 56,750 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: glycerine
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 24 h
Remarks: (ECHA)
The value is given in analogy to the following substances: glycerine
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation - 7 Days
Remarks: (ECHA)
The value is given in analogy to the following substances: glycerine
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative (OECD Test Guideline 429)
Remarks: The value is given in analogy to the following substances: glycerine
Germ cell mutagenicity
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Remarks: The value is given in analogy to the following substances: glycerineTest
Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: glycerineTest
Type: sister chromatid exchange assay
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Remarks: The value is given in analogy to the following substances: glycerineTest
Type: unscheduled DNA synthesis assay
Test system: rat hepatocytes
Method: OECD Test Guideline 482
Result: negative
Remarks: The value is given in analogy to the following substances: glycerineTest
Type: Chromosome aberration test in vitro
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Remarks: The value is given in analogy to the following substances: glycer- ineCarcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Repeated dose toxicity - Rat - male - Oral - 28 Days - No observed adverse effect level - > 1,600 mg/kg
Remarks: (ECHA)
The value is given in analogy to the following substances: glycerine
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.