Chemical Safety Data Sheet MSDS / SDS
NICOTINE SULFATE
Revision Date:2026-03-21Revision Number:1
Product identifier
- Product name: NICOTINE SULFATE
- CBnumber: CB8680448
- CAS: 65-30-5
- EINECS Number: 200-606-7
- Synonyms: ent2,435 ;ai3-02435
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
Hazard statements
H301 Toxic if swalloed
H411 Toxic to aquatic life with long lasting effects
Substance
- Product name: NICOTINE SULFATE
- Synonyms: ent2,435 ;ai3-02435
- CAS: 65-30-5
- EC number: 200-606-7
- MF: C20H30N4O4S
- MW: 422.54
First Aid Measures
General adviceImmediate medical attention is required.
Eye contact
Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. Call a physician immediately.
Skin Contact
Immediate medical attention is required. Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes.
Inhalation
Immediate medical attention is required Remove to fresh air If not breathing, give artificial respiration Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation
Ingestion
Do NOT induce vomiting. Call a physician or poison control center immediately. Never give anything by mouth to an unconscious person. Drink plenty of water.
Self-protection of the first aider
Use personal protective equipment as required. Avoid contact with skin, eyes or clothing.
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Most important symptoms and effects, both acute and delayed
SymptomsNo information available.
Indication of any immediate medical attention and special treatment needed
Note to physiciansTreat symptomatically.
Suitable Extinguishing Media
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
None.
Specific hazards arising from the chemical
Specific hazards arising from the chemicalNo information available.
Hazardous combustion products
Hydrogen sulfide. Carbon oxides. Nitrogen oxides (NOx).
Explosion data
Sensitivity to Mechanical ImpactNo information available.
Sensitivity to Static Discharge
No information available.
Protective equipment and precautions for firefighters
Protective equipment and precautions Wear self-contained breathing apparatus and protective suit.
for firefighters
for firefighters
Personal precautions, protective equipment and emergency procedures
Personal precautionsUse personal protective equipment as required. Keep people away from and upwind of spill/leak.
Environmental precautions
Environmental precautionsPrevent further leakage or spillage if safe to do so. Prevent product from entering drains.
See Section 12 for additional Ecological Information. Should not be released into the environment.
See Section 12 for additional Ecological Information. Should not be released into the environment.
Methods and material for containment and cleaning up
Methods for containmentPrevent further leakage or spillage if safe to do so. Cover powder spill with plastic sheet or tarp to minimize spreading. Dike far ahead of liquid spill for later disposal.
Methods for cleaning up
Cover liquid spill with sand, earth or other non-combustible absorbent material. Cover powder spill with plastic sheet or tarp to minimize spreading. Sweep up and shovel into suitable containers for disposal.
Precautions for safe handling
Advice on safe handlingUse personal protective equipment as required. Avoid contact with skin, eyes or clothing.
Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray.
Do not eat, drink or smoke when using this product.
Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray.
Do not eat, drink or smoke when using this product.
Conditions for safe storage, including any incompatibilities
Storage ConditionsKeep container tightly closed in a dry and well-ventilated place. Keep out of the reach of children. Store at room temperature.
Incompatible materials
None known based on information supplied.
Control parameters
Exposure GuidelinesThis product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies.
Appropriate engineering controls
Engineering ControlsShowers
Eyewash stations
Ventilation systems
Eyewash stations
Ventilation systems
Individual protection measures, such as personal protective equipment
Eye/face protectionTight sealing safety goggles.
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
When using do not eat, drink or smoke. Regular cleaning of equipment, work area and clothing is recommended. Avoid contact with skin, eyes or clothing. Wash hands thoroughly after handling. Keep away from food, drink and animal feeding stuffs.
Information on basic physicochemical properties
- Physical Stateliquid
- AppearanceNo information available
- OdorNo information available
- pHNo information available
- Melting point/freezing pointNo information available
- Boiling pointNo information available
- Flash pointNo information available
- Density1.22
- Evaporation rateNo information available
- Upper flammability limitsNo information available
- Lower flammability limitNo information available
- Vapor pressureNo information available
- Vapor densityNo information available
- Specific gravityNo information available
- Water solubilityNo information available
- Solubility in other solventsNo information available
- Partition coefficientNo information available
- Autoignition temperatureNo information available
- Decomposition temperatureNo information available
- Kinematic viscosityNo information available
- Explosive propertiesNo information available
- Oxidizing propertiesNo information available
- Colourbrown
Reactivity
Not applicable
Chemical stability
Stable under recommended storage conditions.
Possibility of Hazardous Reactions
None under normal processing.
Hazardous polymerization
No information available.
Conditions to avoid
Extremes of temperature and direct sunlight.
Incompatible materials
Strong oxidizing agents.
Hazardous Decomposition Products
Hydrogen sulfide. Carbon oxides. Nitrogen oxides (NOx).
Information on likely routes of exposure
InhalationClassified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.
Information on toxicological effects
SymptomsClassified based on available data. For more details, see section 2.
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Chronic ToxicityProlonged or repeated exposure increases the risk. Possible risk of irreversible effects.
Numerical measures of toxicity - Product Information
Unknown acute toxicityClassified based on available data. For more details, see section 2
The following values are calculated based on chapter 3.1 of the GHS document
ATEmix (oral)
The following values are calculated based on chapter 3.1 of the GHS document
11 mg/kg
ATEmix (dermal)
11 mg/kg
ATEmix (inhalation-dust/mist)
0.1 mg/l
Ecotoxicity
| Chemical Name | Algae/aquatic plants | Fish | Toxicity to Microorganisms | Crustacea |
|---|---|---|---|---|
| (-)-Nicotine hemisulfate salt 65-30-5 | - | 6.29 - 8.5: 96 h Oncorhynchus mykiss mg/L LC50 flow-through 3.16 - 5.88: 96 h Lepomis macrochirus mg/L LC50 flow-through 11 - 13.4: 96 h Pimephales promelas mg/L LC50 flow-through | - | - |
Persistence and degradability No information available. Bioaccumulation No information available. Mobility No information available.
Disposal of wastes
Disposal should be in accordance with applicable regional, national and local laws and regulations. Should not be released into the environment.
Contaminated packaging
Do not reuse container.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used.
US EPA Waste Number
P075
California Hazardous Waste Status
This product contains one or more substances that are listed with the State of California as a hazardous waste.
| Chemical Name | California Hazardous Waste Status |
|---|---|
| (-)-Nicotine hemisulfate salt 65-30-5 | Toxic |
DOT
UN/ID noUN1658
Hazard Class
6.1
Packing Group
II
Proper shipping name
Nicotine sulfate solution
Description
UN1658, Nicotine sulfate solution, 6.1, II, POISON
Emergency Response Guide Number
151
IMDG
UN/ID noUN1658
Hazard Class
6.1
Packing Group
II
Proper shipping name
Nicotine sulphate solution
Description
UN1658, Nicotine sulphate solution, 6.1, II
EmS-No
F-A, S-A
IATA
UN/ID noUN1658
Hazard Class
6.1
Packing Group
II
Proper shipping name
Nicotine sulphate solution
Description
UN1658, Nicotine sulphate solution, 6.1, II
International Inventories
All of the components in the product are on the following Inventory lists
TSCA (United States): Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP) Australia (AICS) Philippines (PICCS)
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
TSCA (United States): Canada (DSL/NDSL) Europe (EINECS/ELINCS/NLP) Australia (AICS) Philippines (PICCS)
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
| Chemical name | TSCA | DSL | NDSL | EINECS | ELINCS | ENCS | IECSC | KECL | PICCS | AICS |
|---|---|---|---|---|---|---|---|---|---|---|
| Water | X | X | - | X | - | - | X | X | X | X |
| (-)-Nicotine hemisulfate salt | X | - | X | X | - | - | - | - | X | X |
US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
SARA 311/312 Hazard Categories
Acute health hazardNo
Chronic Health Hazard
Yes
Fire hazard
No
Sudden release of pressure hazard
No
Reactive hazard
No
CWA (Clean Water Act)
This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40
CFR 122.42).
CFR 122.42).
US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
| Chemical Name | New Jersey | Massachusetts | Pennsylvania |
|---|---|---|---|
| (-)-Nicotine hemisulfate salt 65-30-5 | X | X | X |
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.