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ChemicalBook >> CAS DataBase List >> 10-Hydroxycamptothecin

10-Hydroxycamptothecin

10-Hydroxycamptothecin price.
  • $7 - $1795
  • Product name: 10-Hydroxycamptothecin
  • CAS: 19685-09-7
  • MF: C20H16N2O5
  • MW: 364.35
  • EINECS:805-668-4
  • MDL Number:MFCD00189425
  • Synonyms:Camptothecae Acuminatae extract;hydrate,(s)-dihydroxy ;hydroxy-camptotheci ;Hydroxycamptothencine;(20S)-10-HYDROXYCAMPTOTHECIN 98%;(20S)-10-Hydroxycamptothecin;HYDROCAMPTOTHECINE;CAMPTOTHECIN, 10-HYDROXY(SH)
Price93 Properties Safety Information Description
93 prices
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  • aablocks
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  • 10mM(in1mLDMSO)
  • 10mM(in 1mL DMSO)
  • 5mg
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  • Manufactureraablocks
  • Product numberAA0032DK
  • Product description(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
  • Packaging100mg
  • Price$7
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0032DK
  • Product description(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
  • Packaging250mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0032DK
  • Product description(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
  • Packaging1g
  • Price$32
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0032DK
  • Product description(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98%
  • Packaging5g
  • Price$96
  • Updated2026-05-28
  • Buy
  • ManufacturerAbosyn
  • Product number61-3021
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98%
  • Packaging1g
  • Price$306
  • Updated2021-12-16
  • Buy
  • ManufacturerAccelPharmtech
  • Product numberFB2418
  • Product description10-HydroxyCamptothecin 99%
  • Packaging5G
  • Price$310
  • Updated2021-12-16
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  • ManufacturerAccelPharmtech
  • Product numberFB2418
  • Product description10-HydroxyCamptothecin 99%
  • Packaging5G
  • Price$310
  • Updated2026-05-21
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  • ManufacturerAccelPharmtech
  • Product numberFB2418
  • Product description10-HydroxyCamptothecin 99%
  • Packaging10G
  • Price$410
  • Updated2026-05-21
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  • ManufacturerACHEMBLOCK
  • Product numberU106224
  • Product description10-HYDROXYCAMPTOTHECIN 98.00%
  • Packaging100G
  • Price$1795
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberH577
  • Product description10-Hydroxycamptothecin 98%(HPLC)
  • Packaging5g
  • Price$190
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ11456
  • Product description10-Hydroxycamptothecin
  • Packaging100mg
  • Price$98
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product numberJ99238
  • Product description10-Hydroxycamptothecin 95%
  • Packaging5g
  • Price$142
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberH577
  • Product description10-Hydroxycamptothecin 98%(HPLC)
  • Packaging1g
  • Price$75
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ99238
  • Product description10-Hydroxycamptothecin 95%
  • Packaging1g
  • Price$56
  • Updated2026-06-04
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  • ManufacturerAK Scientific
  • Product numberJ11456
  • Product description10-Hydroxycamptothecin
  • Packaging25mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA155153
  • Product description(S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+%
  • Packaging100mg
  • Price$16
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0032DK (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% 100mg $7 2026-05-28 Buy
aablocks AA0032DK (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% 250mg $10 2026-05-28 Buy
aablocks AA0032DK (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% 1g $32 2026-05-28 Buy
aablocks AA0032DK (4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98% 5g $96 2026-05-28 Buy
Abosyn 61-3021 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 95%-98% 1g $306 2021-12-16 Buy
AccelPharmtech FB2418 10-HydroxyCamptothecin 99% 5G $310 2021-12-16 Buy
AccelPharmtech FB2418 10-HydroxyCamptothecin 99% 5G $310 2026-05-21 Buy
AccelPharmtech FB2418 10-HydroxyCamptothecin 99% 10G $410 2026-05-21 Buy
ACHEMBLOCK U106224 10-HYDROXYCAMPTOTHECIN 98.00% 100G $1795 2026-05-27 Buy
AK Scientific H577 10-Hydroxycamptothecin 98%(HPLC) 5g $190 2026-06-04 Buy
AK Scientific J11456 10-Hydroxycamptothecin 100mg $98 2021-12-16 Buy
AK Scientific J99238 10-Hydroxycamptothecin 95% 5g $142 2026-06-04 Buy
AK Scientific H577 10-Hydroxycamptothecin 98%(HPLC) 1g $75 2026-06-04 Buy
AK Scientific J99238 10-Hydroxycamptothecin 95% 1g $56 2026-06-04 Buy
AK Scientific J11456 10-Hydroxycamptothecin 25mg $39 2021-12-16 Buy
Ambeed A155153 (S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione 98+% 100mg $16 2021-12-16 Buy
Next Last

Properties

Melting point :265-270°C
Boiling point :820.7±65.0 °C(Predicted)
Density :1.60
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
pka :8.93±0.40(Predicted)
form :powder to crystal
color :White to Yellow to Orange
InChI :InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3/t20-/m0/s1
InChIKey :HAWSQZCWOQZXHI-FQEVSTJZSA-N
SMILES :N1C2C(=CC(O)=CC=2)C=C2CN3C(C=12)=CC1[C@](CC)(O)C(=O)OCC=1C3=O
CAS DataBase Reference :19685-09-7(CAS DataBase Reference)

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)Health Hazard (GHS08)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Description

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.

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Suppliers and manufacturers

Shaanxi Xianhe Biotech Co., Ltd
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career henan chemical co
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NanJing Spring & Autumn Biological Engineering CO., LTD.
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Capot Chemical Co.,Ltd.
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