2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
![2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE price.](/CAS/GIF/182004-65-5.gif)
|
- $14 - $1853
- Product name: 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE
- CAS: 182004-65-5
- MF: C17H21N3O6S2
- MW: 427.49
- EINECS:
- MDL Number:MFCD00952138
- Synonyms:Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate;Carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate;KB-R7943;2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE;2-(2-(4-(4-NITROBENZYLOXY)PHENYL)ETHYL)ISOTHIOUREA, METHANE SULFONATE;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate;4-((4-Nitrobenzyl)oxy)phenethyl carbaMiMidothioate Methanesulfonate;S-[4-[(4-Nitrobenzyl)oxy]phenethyl]isothiourea Methanesulfonate
66 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AHH
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Cayman Chemical
- Chem-Impex
- ChemScene
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 1g
- 10mM*1mLinDMSO
- 250.00mg
- 2.5mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- 10
- 1 unit
- 50
- 5 mg
- 1mg
- 10mM(in1mLDMSO)
- 5mg
- 10mg
- 25mg
- 50mg
- 0.05g
- 100mg
- 250MG
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA00236P
- Product description2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate 98%
- Packaging1mg
- Price$14
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00236P
- Product description2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate 98%
- Packaging5mg
- Price$33
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00236P
- Product description2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate 98%
- Packaging10mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00236P
- Product description2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate
- Packaging25mg
- Price$125
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00236P
- Product description2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate ≥98%(HPLC)
- Packaging50mg
- Price$187
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00236P
- Product description2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate
- Packaging100mg
- Price$304
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238725
- Product descriptionKB-R7943 mesylate 98%
- Packaging100MG
- Price$295
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238725
- Product descriptionKB-R7943 mesylate 98%
- Packaging250MG
- Price$530
- Updated2026-05-27
- Buy
- ManufacturerAHH
- Product numberMT-19776
- Product description2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate 95%
- Packaging0.05g
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberMT-19776
- Product description2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate 97%
- Packaging0.05g
- Price$370
- Updated2026-05-25
- Buy
- ManufacturerAHH
- Product numberMT-19776
- Product description2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate 97%
- Packaging0.05g
- Price$370
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product numberY0457
- Product description2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate
- Packaging250mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA722708
- Product descriptionKB-R7943Mesylate 95+%
- Packaging50mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA722708
- Product descriptionKB-R7943Mesylate 95+%
- Packaging5mg
- Price$56
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA722708
- Product descriptionKB-R7943Mesylate 95+%
- Packaging10mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3525
- Product descriptionKB-R7943 mesylate
- Packaging10mM(in1mLDMSO)
- Price$99
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00236P | 2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate 98% | 1mg | $14 | 2026-05-28 | Buy |
| aablocks | AA00236P | 2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate 98% | 5mg | $33 | 2026-05-28 | Buy |
| aablocks | AA00236P | 2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate 98% | 10mg | $52 | 2026-05-28 | Buy |
| aablocks | AA00236P | 2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate | 25mg | $125 | 2026-05-28 | Buy |
| aablocks | AA00236P | 2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate ≥98%(HPLC) | 50mg | $187 | 2026-05-28 | Buy |
| aablocks | AA00236P | 2-[2-[4-(4-Nitrobenzyloxy)Phenyl]Ethyl]Isothiourea Mesylate | 100mg | $304 | 2026-05-28 | Buy |
| ACHEMBLOCK | Z238725 | KB-R7943 mesylate 98% | 100MG | $295 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238725 | KB-R7943 mesylate 98% | 250MG | $530 | 2026-05-27 | Buy |
| AHH | MT-19776 | 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate 95% | 0.05g | $370 | 2021-12-16 | Buy |
| AHH | MT-19776 | 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate 97% | 0.05g | $370 | 2026-05-25 | Buy |
| AHH | MT-19776 | 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate 97% | 0.05g | $370 | 2026-05-26 | Buy |
| AK Scientific | Y0457 | 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioureamesylate | 250mg | $335 | 2021-12-16 | Buy |
| Ambeed | A722708 | KB-R7943Mesylate 95+% | 50mg | $240 | 2021-12-16 | Buy |
| Ambeed | A722708 | KB-R7943Mesylate 95+% | 5mg | $56 | 2021-12-16 | Buy |
| Ambeed | A722708 | KB-R7943Mesylate 95+% | 10mg | $95 | 2021-12-16 | Buy |
| ApexBio Technology | A3525 | KB-R7943 mesylate | 10mM(in1mLDMSO) | $99 | 2026-05-06 | Buy |
Properties
Melting point :>214°C (dec.)
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :White crystalline solid
color :Tan
Water Solubility :water: 4mg/mL
DMSO: 40mg/mL Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKey :WGIKEBHIKKWJLG-UHFFFAOYSA-N
SMILES :S(O)(=O)(=O)C.C(C1C=CC(N(=O)=O)=CC=1)OC1C=CC(CCSC(N)=N)=CC=1
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 50 mg/ml).
form :White crystalline solid
color :Tan
Water Solubility :water: 4mg/mL
DMSO: 40mg/mL Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChIKey :WGIKEBHIKKWJLG-UHFFFAOYSA-N
SMILES :S(O)(=O)(=O)C.C(C1C=CC(N(=O)=O)=CC=1)OC1C=CC(CCSC(N)=N)=CC=1
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
The Na+/Ca2+ exchanger (NCX) is a major regulator of intracellular calcium concentration that is largely expressed in cardiac sarcolemma (NCX1) but also in brain and skeletal muscle (NCX2). KB-R7943 is an isothiourea derivative that selectively inhibits the reverse mode of NCX1 (IC50 = 1.2-2.4 μM), preventing intracellular sodium-dependent calcium uptake in whole cells. It is much less potent at preventing extracellular sodium-dependent calcium efflux from intact cells (IC50 > 30 μM). In cultured hippocampal neurons, KB-R7943 exhibits neuroprotection from glutamate-induced excitotoxicity by blocking NMDA receptor-mediated activity (IC50 = 13.4 μM) and inhibiting complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM). KB-R7943 has also been shown to block transient receptor potential canonical channels, which are important mediators of calcium-dependent signal transduction.Related product price
-
IONOMYCIN
$44-6400 -
SKF 96365 HYDROCHLORIDE
$20-1600 -
67469-78-7
$5-1950
Suppliers and manufacturers
![2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE](https://img.chemicalbook.com/ProductImageEN/2020-1/small/7ef85ae9-c56c-418c-a202-ae81fb168270.jpg){kind=small}
Henan Aochuang Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
CONIER CHEM AND PHARMA LIMITED
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Hefei Hirisun Pharmatech Co., Ltd
TargetMol Chemicals Inc.
Wuhan Topule Biopharmaceutical Co., Ltd
KB-R7943 mesylate
CAS:182004-65-5