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ChemicalBook >> CAS DataBase List >> (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide

(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide

(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide price.
  • $50 - $4230
  • Product name: (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide
  • CAS: 273404-37-8
  • MF: C24H33ClN4O6
  • MW: 508.99
  • EINECS:
  • MDL Number:MFCD11100350
  • Synonyms:(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide;Belnacasan (VX765);N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide;CS-387;VX 765; VX-765; VX765. BELNACASAN;(2S)-1-[(2S)-2-[(4-amino-3-chlorophenyl)formamido]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide;Belnacasan;L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-
Price34 Properties Safety Information Description
34 prices
Selected condition：
Brand
  • AccelPharmtech
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Ark Pharm
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
Package
  • 1mg
  • 5MG
  • 10MG
  • 25MG
  • 50mg
  • 100mg
  • 250mg
  • 500mg
  • 1G
  • ManufacturerAccelPharmtech
  • Product numberLX1651
  • Product description(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 98.00%
  • Packaging25MG
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0257
  • Product descriptionVX-765
  • Packaging50mg
  • Price$498
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY0257
  • Product descriptionVX-765
  • Packaging250mg
  • Price$1501
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging5MG
  • Price$460
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging10MG
  • Price$484
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging50MG
  • Price$613
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000874
  • Product descriptionVX-765 99.00%
  • Packaging1G
  • Price$4230
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8238
  • Product descriptionVX-765
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8238
  • Product descriptionVX-765
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60139
  • Product descriptionBelnacasan(VX-765) ≥98%
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging1mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging50mg
  • Price$521
  • Updated2021-12-16
  • Buy
  • ManufacturerArk Pharm
  • Product numberP000532862
  • Product descriptionVX-765 98+%
  • Packaging100mg
  • Price$852
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFV137735
  • Product descriptionVX 765
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AccelPharmtech LX1651 (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide 98.00% 25MG $240 2021-12-16 Buy
AK Scientific Y0257 VX-765 50mg $498 2021-12-16 Buy
AK Scientific Y0257 VX-765 250mg $1501 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 5MG $460 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 10MG $484 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 50MG $613 2021-12-16 Buy
American Custom Chemicals Corporation INB0000874 VX-765 99.00% 1G $4230 2021-12-16 Buy
ApexBio Technology A8238 VX-765 10mg $100 2021-12-16 Buy
ApexBio Technology A8238 VX-765 100mg $450 2021-12-16 Buy
Arctom CFN60139 Belnacasan(VX-765) ≥98% 10mg $238 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 1mg $50 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 5mg $120 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 10mg $160 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 50mg $521 2021-12-16 Buy
Ark Pharm P000532862 VX-765 98+% 100mg $852 2021-12-16 Buy
Biosynth Carbosynth FV137735 VX 765 10mg $95 2021-12-16 Buy
Next Last

Properties

Boiling point :779.0±60.0 °C(Predicted)
Density :1.32
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
pka :12.60±0.40(Predicted)
form :solid
color :Off-white to white
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :SJDDOCKBXFJEJB-MOKWFATOSA-N
SMILES :C(N[C@H]1CC(=O)O[C@H]1OCC)(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)(C)C)NC(=O)C1=CC=C(N)C(Cl)=C1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Belnacasan (273404-37-8) is a prodrug of VRT-043198, a potent (Ki = 0.8 nM ICE/caspase-1; <0.6nM caspase-4) and selective inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases.1 VRT-043198 ICE/caspase-1 IC50 = 0.67 μM PBMCs, 1.0 μM whole blood.? It inhibited the release of IL-1b and IL-18 from human monocytes in vitro and their production in vivo in models of inflammation. Belnacasan inhibited the activation and expression of the NLRP3 Inflammasome leading to moderation of depressive-like behaviors induced by chronic mild stress2 and prevention of glial pyroptosis in multiple sclerosis models3. It inhibited pyroptosis in vascular smooth muscle cells during atherogenesis suggesting a possible therapeutic effect in treating atherosclerotic disease.4 Belnacasan reduced acute seizures and drug resistant chronic epileptic activity in mice5 and provided neuroprotection in two rat models of temporal lobe epilepsy6.? It also displays protective effects in models of stroke7and Alzheimer’s disease8.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
Belnacasan
$31.00 /2mg
Belnacasan CAS:273404-37-8
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei Jusheng Technology Co.,Ltd.
Changzhou PBpharmaceutical R&D Co.,Ltd
BOC Sciences
Zhengzhou Alfa Chemical Co.,Ltd
Hubei Ipure Biology Co., Ltd
HONG KONG IPURE BIOLOGY CO.,LIMITED
Dideu Industries Group Limited