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ChemicalBook >> CAS DataBase List >> 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione

2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione price.
  • $44 - $800
  • Product name: 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
  • CAS: 332382-54-4
  • MF: C22H22N2O3
  • MW: 362.42
  • EINECS:
  • MDL Number:MFCD01956583
  • Synonyms:2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione;TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem;2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione;2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindoline-1,3-dione;BAS 01520422;BIM-0009825.P001;CBMicro_009667;ChemDiv1_023217
Price25 Properties Safety Information Description
25 prices
Selected condition：
Brand
  • aablocks
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 50
  • 10
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 1 unit
  • Manufactureraablocks
  • Product numberAA00CN43
  • Product description2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 97%
  • Packaging250mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00CN43
  • Product description2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 97%
  • Packaging1g
  • Price$180
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00CN43
  • Product description2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 97%
  • Packaging5g
  • Price$800
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number0471AE
  • Product description2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
  • Packaging10mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number332382544
  • Product description2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione
  • Packaging5g
  • Price$369.6
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0265719
  • Product description2-[2-OXO-2-(2,2,4-TRIMETHYL-3,4-DIHYDROQUINOLIN-1(2H)-YL)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE 95.00%
  • Packaging5MG
  • Price$498.51
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5700
  • Product descriptionMLSA1
  • Packaging10mg
  • Price$171
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5700
  • Product descriptionMLSA1
  • Packaging50mg
  • Price$718
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29958
  • Product descriptionML-SA1
  • Packaging10mg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29958
  • Product descriptionML-SA1
  • Packaging50mg
  • Price$183
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29958
  • Product descriptionML-SA1
  • Packaging100mg
  • Price$321
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29958
  • Product descriptionML-SA1
  • Packaging250mg
  • Price$586
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM223212
  • Product description2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione 95%
  • Packaging5g
  • Price$329
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11142865
  • Product description2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione 95+%
  • Packaging5g
  • Price$352
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number066361
  • Product description2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
  • Packaging500mg
  • Price$109
  • Updated2021-12-16
  • Buy
  • ManufacturerMatrix Scientific
  • Product number066361
  • Product description2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
  • Packaging1g
  • Price$129
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00CN43 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 97% 250mg $80 2021-12-16 Buy
aablocks AA00CN43 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 97% 1g $180 2021-12-16 Buy
aablocks AA00CN43 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 97% 5g $800 2021-12-16 Buy
AK Scientific 0471AE 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 10mg $147 2021-12-16 Buy
Alichem 332382544 2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione 5g $369.6 2021-12-16 Buy
American Custom Chemicals Corporation CHM0265719 2-[2-OXO-2-(2,2,4-TRIMETHYL-3,4-DIHYDROQUINOLIN-1(2H)-YL)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE 95.00% 5MG $498.51 2021-12-16 Buy
ApexBio Technology B5700 MLSA1 10mg $171 2021-12-16 Buy
ApexBio Technology B5700 MLSA1 50mg $718 2021-12-16 Buy
Cayman Chemical 29958 ML-SA1 10mg $44 2024-03-01 Buy
Cayman Chemical 29958 ML-SA1 50mg $183 2024-03-01 Buy
Cayman Chemical 29958 ML-SA1 100mg $321 2024-03-01 Buy
Cayman Chemical 29958 ML-SA1 250mg $586 2024-03-01 Buy
Chemenu CM223212 2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione 95% 5g $329 2021-12-16 Buy
Crysdot CD11142865 2-(2-oxo-2-(2,2,4-Trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione 95+% 5g $352 2021-12-16 Buy
Matrix Scientific 066361 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 500mg $109 2021-12-16 Buy
Matrix Scientific 066361 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione 1g $129 2021-12-16 Buy
Next Last

Properties

Boiling point :546.7±43.0 °C(Predicted)
Density :1.226±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
form :powder
pka :1.16±0.60(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P501 Dispose of contents/container to..…

Description

ML-SA1 (332382-54-4) is a?TRPML 1,2 and 3 channel activator.1?Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2?ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2?(1 μM).2?Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+?release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3?Reduces intralysosomal Ca2+?level rescuing abnormal lysosomal storage in FIG4-deficient cells.4

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Suppliers and manufacturers

TargetMol Chemicals Inc.
ML-SA1
$47.00 /5mg
ML-SA1 CAS:332382-54-4
ATK CHEMICAL COMPANY LIMITED
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Nantong HI-FUTURE Biology Co., Ltd.
Wuhan Topule Biopharmaceutical Co., Ltd
HANGZHOU LEAP CHEM CO., LTD.
Aladdin Scientific Shanghai Jian Chao Chemical Technology Co., Ltd. ShangHai Caerulum Pharma Discovery Co., Ltd.