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ChemicalBook >> CAS DataBase List >> Disodium clodronate tetrahydrate

Disodium clodronate tetrahydrate

Disodium clodronate tetrahydrate price.
  • $37 - $775
  • Product name: Disodium clodronate tetrahydrate
  • CAS: 88416-50-6
  • MF: CH7Cl2NaO7P2
  • MW: 286.9
  • EINECS:
  • MDL Number:MFCD02940846
  • Synonyms:DICHLOROMETHYLENE-BISPHOSPHONATE, DISODIUM TETRAHYDRATE;CLASTEON;CLASTOBAN;CLODRONIC ACID, DISODIUM SALT, TETRAHYDRATE;CLODRONATE, DISODIUM SALT, TETRAHYDRATE;CLODRONATE, DISODIUM, TETRAHYDRATE;BONEFOS;(Dichlorormethylene)diphosphonic acid, disodium salt
18 prices
Selected condition:
Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • DC Chemicals
  • Sigma-Aldrich
  • TCI Chemical
  • Usbiological
Package
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • y0000888
  • 1g
  • 2g
  • 5G
  • 10g
  • 25g
  • 5 mg
  • ManufacturerAK Scientific
  • Product number2382AH
  • Product descriptionDisodium Clodronate Tetrahydrate
  • Packaging1g
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD75417
  • Product descriptionDisodium clodronate tetrahydrate
  • Packaging1g
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD75417
  • Product descriptionDisodium clodronate tetrahydrate
  • Packaging2g
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD75417
  • Product descriptionDisodium clodronate tetrahydrate
  • Packaging5G
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD75417
  • Product descriptionDisodium clodronate tetrahydrate
  • Packaging10g
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD75417
  • Product descriptionDisodium clodronate tetrahydrate
  • Packaging25g
  • Price$775
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16134
  • Product descriptionClodronate (sodium salt hydrate) ≥95%
  • Packaging5mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16134
  • Product descriptionClodronate (sodium salt hydrate) ≥95%
  • Packaging10mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16134
  • Product descriptionClodronate (sodium salt hydrate) ≥95%
  • Packaging50mg
  • Price$108
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16134
  • Product descriptionClodronate (sodium salt hydrate) ≥95%
  • Packaging100mg
  • Price$178
  • Updated2024-03-01
  • Buy
  • ManufacturerChem-Impex
  • Product number37807
  • Product descriptionClodronatedisodiumtetrahydrate,98%(Assayonanhydrousbasis) 98%(Assayonanhydrousbasis)
  • Packaging5G
  • Price$332.64
  • Updated2021-12-16
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  • ManufacturerDC Chemicals
  • Product numberDC9087
  • Product descriptionClodronate disodium tetrahydrate >98%
  • Packaging1g
  • Price$300
  • Updated2021-12-16
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  • ManufacturerSigma-Aldrich
  • Product number233183
  • Product descriptionClodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem
  • Packaging10mg
  • Price$146
  • Updated2025-07-31
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  • ManufacturerSigma-Aldrich
  • Product numberY0000888
  • Product descriptionClodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard
  • Packagingy0000888
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0000888
  • Product descriptionClodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard
  • Packaging5 mg
  • Price$156
  • Updated2025-07-31
  • Buy
  • ManufacturerTCI Chemical
  • Product numberD4160
  • Product descriptionDisodium Clodronate Tetrahydrate >98.0%(T)
  • Packaging1g
  • Price$86
  • Updated2025-07-31
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 2382AH Disodium Clodronate Tetrahydrate 1g $168 2021-12-16 Buy
Biosynth Carbosynth FD75417 Disodium clodronate tetrahydrate 1g $50 2021-12-16 Buy
Biosynth Carbosynth FD75417 Disodium clodronate tetrahydrate 2g $80 2021-12-16 Buy
Biosynth Carbosynth FD75417 Disodium clodronate tetrahydrate 5G $165 2021-12-16 Buy
Biosynth Carbosynth FD75417 Disodium clodronate tetrahydrate 10g $320 2021-12-16 Buy
Biosynth Carbosynth FD75417 Disodium clodronate tetrahydrate 25g $775 2021-12-16 Buy
Cayman Chemical 16134 Clodronate (sodium salt hydrate) ≥95% 5mg $37 2024-03-01 Buy
Cayman Chemical 16134 Clodronate (sodium salt hydrate) ≥95% 10mg $62 2024-03-01 Buy
Cayman Chemical 16134 Clodronate (sodium salt hydrate) ≥95% 50mg $108 2024-03-01 Buy
Cayman Chemical 16134 Clodronate (sodium salt hydrate) ≥95% 100mg $178 2024-03-01 Buy
Chem-Impex 37807 Clodronatedisodiumtetrahydrate,98%(Assayonanhydrousbasis) 98%(Assayonanhydrousbasis) 5G $332.64 2021-12-16 Buy
DC Chemicals DC9087 Clodronate disodium tetrahydrate >98% 1g $300 2021-12-16 Buy
Sigma-Aldrich 233183 Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem 10mg $146 2025-07-31 Buy
Sigma-Aldrich Y0000888 Clodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard y0000888 $153 2024-03-01 Buy
Sigma-Aldrich Y0000888 Clodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard 5 mg $156 2025-07-31 Buy
TCI Chemical D4160 Disodium Clodronate Tetrahydrate >98.0%(T) 1g $86 2025-07-31 Buy

Properties

storage temp. :2-8°C
solubility :Soluble in Water (up to at least 10 mg/ml)
form :White solid
color :White
Water Solubility :water: 1mg/mL
Merck :14,2371
Stability :Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
InChIKey :XWHPUCFOTRBMGS-UHFFFAOYSA-L

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P273 Avoid release to the environment.
P281 Use personal protective equipment as required.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.

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