Brigatinib
|
- $5 - $1504.5
- Product name: Brigatinib
- CAS: 1197953-54-0
- MF: C29H39ClN7O2P
- MW: 584.09
- EINECS:1592732-453-0
- MDL Number:MFCD29472221
- Synonyms:Brigatinib;AP26113 (Brigatinib);Brigatinib, AP26113;5-Chloro-N4-[2-(dimethylphosphinyl)phenyl]-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-2,4-pyrimidinediamine;5-chloro-N4-(2-(dimethylphosphoryl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine;brigatib;140455;Bogtinib (AP26113)
55 prices
Selected condition：
Brand
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 250mg
- 10mM*1mLinDMSO
- 100MG
- 500mg
- 1G
- 5G
- ManufacturerACHEMBLOCK
- Product numberL13974
- Product descriptionBrigatinib 98%
- Packaging100MG
- Price$15
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13974
- Product descriptionBrigatinib 98%
- Packaging1G
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberL13974
- Product descriptionBrigatinib 98%
- Packaging5G
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-B0374-M005
- Product descriptionBrigatinib ≥98%(HPLC)
- Packaging5mg
- Price$79
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberCDX-B0374-M025
- Product descriptionBrigatinib ≥98%(HPLC)
- Packaging25mg
- Price$316
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number9856BB
- Product descriptionBrigatinib
- Packaging500mg
- Price$522
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9856BB
- Product descriptionBrigatinib
- Packaging50mg
- Price$171
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9856BB
- Product descriptionBrigatinib
- Packaging100mg
- Price$239
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging5g
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging1g
- Price$32
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging50mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging100mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA151843
- Product description(2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+%
- Packaging250mg
- Price$13
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0028650
- Product descriptionBRIGATINIB 95.00%
- Packaging5MG
- Price$499.63
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberSLK-S8229
- Product descriptionBrigatinib (AP26113) 99.91%
- Packaging100mg
- Price$644
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12857
- Product descriptionBrigatinib 99.98%
- Packaging50mg
- Price$266
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | L13974 | Brigatinib 98% | 100MG | $15 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13974 | Brigatinib 98% | 1G | $40 | 2026-05-27 | Buy |
| ACHEMBLOCK | L13974 | Brigatinib 98% | 5G | $110 | 2026-05-27 | Buy |
| Adipogen Life Sciences | CDX-B0374-M005 | Brigatinib ≥98%(HPLC) | 5mg | $79 | 2026-05-06 | Buy |
| Adipogen Life Sciences | CDX-B0374-M025 | Brigatinib ≥98%(HPLC) | 25mg | $316 | 2026-05-06 | Buy |
| AK Scientific | 9856BB | Brigatinib | 500mg | $522 | 2021-12-16 | Buy |
| AK Scientific | 9856BB | Brigatinib | 50mg | $171 | 2021-12-16 | Buy |
| AK Scientific | 9856BB | Brigatinib | 100mg | $239 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 5g | $110 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 1g | $32 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 50mg | $5 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 100mg | $8 | 2021-12-16 | Buy |
| Ambeed | A151843 | (2-((5-Chloro-2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphineoxide 98+% | 250mg | $13 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0028650 | BRIGATINIB 95.00% | 5MG | $499.63 | 2021-12-16 | Buy |
| Arctom | SLK-S8229 | Brigatinib (AP26113) 99.91% | 100mg | $644 | 2026-05-26 | Buy |
| Arctom | HY-12857 | Brigatinib 99.98% | 50mg | $266 | 2026-05-26 | Buy |
Properties
Melting point :>203°C (dec.)
Boiling point :781.8±70.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (1 mg/ml with warming)
form :solid
pka :8.14±0.42(Predicted)
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :AILRADAXUVEEIR-UHFFFAOYSA-N
SMILES :C1(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
CAS DataBase Reference :1197953-54-0
Boiling point :781.8±70.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :Soluble in DMSO (1 mg/ml with warming)
form :solid
pka :8.14±0.42(Predicted)
color :White to off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :AILRADAXUVEEIR-UHFFFAOYSA-N
SMILES :C1(NC2=CC=C(N3CCC(N4CCN(C)CC4)CC3)C=C2OC)=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1
CAS DataBase Reference :1197953-54-0
Safety Information
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Description
Brigatinib is a small molecule inhibitor of both ALK and EGFR [195]. In preclinical models, “triple-mutant EGFR”-positive cells (activating EGFR mutation/ T790M/C797S) responded to the combination of brigatinib with an anti-EGFR monoclonal antibody, cetuximab or panitumumab [196]. Single-agent activity of brigatinib in a phase I/II trial was only 5% [197], possibly compounded by low plasma concentrations [196], but the addition of an anti-EGFR monoclonal antibody remains to be clinically tested. The preclinical data with brigatinib and EAI045in laboratory models with a C797S mutation demonstrate that combination therapies with an anti-EGFR monoclonal antibody may lead to overcoming resistance to osimertinib.More related product prices
PF-06463922 Crizotinib AP26113 BKM120 (NVP-BKM120, Buparlisib) Ceritinib (LDK378) INCB28060 Olaparib Afatinib (BIBW 2992) Dacomitinib (PF299804) 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Pazopanib Everolimus AZD-9291 Enzalutamide (MDV3100) BIBW2992 DiMaleateRelated product price
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Suppliers and manufacturers
Enki Biopharmaceuticals (Shanghai) Limited
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BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
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Capot Chemical Co.,Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Brigatinib
CAS:1197953-54-0