GO 6976
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- $42 - $3900
- Product name: GO 6976
- CAS: 136194-77-9
- MF: C24H18N4O
- MW: 378.43
- EINECS:200-258-5
- MDL Number:MFCD00236434
- Synonyms:InSolution G 6976 - CAS 136194-77-9 - Calbiochem;InSolution? G? 6976 ;5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;Go6976,5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;PD406976;12-(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO(2,3-A)PYRROLO(3,4-C)-CARBAZOLE;12-2(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE;GO 6976
41 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 500μg
- 1mg
- 2mg
- 2.5mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 500U
- 1g
- 1ml
- Manufactureraablocks
- Product numberAA009A7L
- Product descriptionGo6976 98%
- Packaging1mg
- Price$42
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009A7L
- Product descriptionGo6976 ≥98%
- Packaging5mg
- Price$122
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009A7L
- Product descriptionGo6976 ≥98%
- Packaging25mg
- Price$458
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009A7L
- Product descriptionGo6976 ≥98%
- Packaging50mg
- Price$823
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228829
- Product descriptionGo6976 96%
- Packaging100MG
- Price$1070
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228829
- Product descriptionGo6976 96%
- Packaging25MG
- Price$475
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228829
- Product descriptionGo6976 96%
- Packaging5MG
- Price$195
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5462
- Product descriptionGo6976
- Packaging50mg
- Price$1880
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8341
- Product descriptionGo6976
- Packaging25mg
- Price$441
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8341
- Product descriptionGo 6976
- Packaging25mg
- Price$450
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8341
- Product descriptionGo 6976
- Packaging5mg
- Price$160
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8341
- Product descriptionGo6976
- Packaging5mg
- Price$147
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60288
- Product descriptionGo6976
- Packaging5mg
- Price$338
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberBG168444
- Product descriptionGo 6976
- Packaging5mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberBG168444
- Product descriptionGo 6976
- Packaging25mg
- Price$1750
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberBG168444
- Product descriptionGo 6976
- Packaging2mg
- Price$280
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009A7L | Go6976 98% | 1mg | $42 | 2026-05-28 | Buy |
| aablocks | AA009A7L | Go6976 ≥98% | 5mg | $122 | 2026-05-28 | Buy |
| aablocks | AA009A7L | Go6976 ≥98% | 25mg | $458 | 2026-05-28 | Buy |
| aablocks | AA009A7L | Go6976 ≥98% | 50mg | $823 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228829 | Go6976 96% | 100MG | $1070 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228829 | Go6976 96% | 25MG | $475 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228829 | Go6976 96% | 5MG | $195 | 2026-05-27 | Buy |
| AK Scientific | SYN5462 | Go6976 | 50mg | $1880 | 2021-12-16 | Buy |
| ApexBio Technology | A8341 | Go6976 | 25mg | $441 | 2021-12-16 | Buy |
| ApexBio Technology | A8341 | Go 6976 | 25mg | $450 | 2026-05-06 | Buy |
| ApexBio Technology | A8341 | Go 6976 | 5mg | $160 | 2026-05-06 | Buy |
| ApexBio Technology | A8341 | Go6976 | 5mg | $147 | 2021-12-16 | Buy |
| Arctom | CFN60288 | Go6976 | 5mg | $338 | 2021-12-16 | Buy |
| Biosynth | BG168444 | Go 6976 | 5mg | $450 | 2021-12-16 | Buy |
| Biosynth | BG168444 | Go 6976 | 25mg | $1750 | 2021-12-16 | Buy |
| Biosynth | BG168444 | Go 6976 | 2mg | $280 | 2021-12-16 | Buy |
Properties
Melting point :>221°C (dec.)
Boiling point :652.3±55.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form :Off-white solid
pka :14.39±0.20(Predicted)
color :White to Off-White
InChI :InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChIKey :VWVYILCFSYNJHF-UHFFFAOYSA-N
SMILES :N1(C)C2=C(C=CC=C2)C2=C1C1N(CCC#N)C3=C(C=1C1CNC(=O)C=12)C=CC=C3
Boiling point :652.3±55.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form :Off-white solid
pka :14.39±0.20(Predicted)
color :White to Off-White
InChI :InChI=1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChIKey :VWVYILCFSYNJHF-UHFFFAOYSA-N
SMILES :N1(C)C2=C(C=CC=C2)C2=C1C1N(CCC#N)C3=C(C=1C1CNC(=O)C=12)C=CC=C3
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
G? 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1. G? 6976 also inhibits the checkpoint kinases Chk1/2. It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.Related product price
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1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97
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