Welcome to chemicalbook!
China English Japan Germany
010-86108875
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structure Search
RFQ
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook Sign in

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook >> CAS DataBase List >> GSK-3326595

GSK-3326595

GSK-3326595 price.
  • $12 - $2450
  • Product name: GSK-3326595
  • CAS: 1616392-22-3
  • MF: C24H32N6O3
  • MW: 452.55
  • EINECS:
  • MDL Number:MFCD29991177
  • Synonyms:6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide;4-Pyrimidinecarboxamide, 6-[(1-acetyl-4-piperidinyl)amino]-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-;GSK-3326595,EPZ-015938;EPZ-015938 (GSK3326595);4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamid;6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1;EPZ015938; 6-[(1-ACETYLPIPERIDIN-4-YL)AMINO]-N-[(2S)-2-HYDROXY-3-(1;2;3;4-TETRAHYDROISOQUINOLIN-2-YL)PROPYL]PYRIMIDINE-4-CARBOXAMID;EPZ015938; EPZ 015938; EPZ-015938
Price59 Properties Safety Information Description
59 prices
Selected condition：
Brand
  • A2B
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Alichem
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 5mg
  • 10mg
  • 25.00mg
  • 25mg
  • 50.00mg
  • 50mg
  • 100mg
  • 100.00mg
  • 200mg
  • 250mg
  • 1g
  • 5G
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging1mg
  • Price$12
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging5mg
  • Price$22
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging10mg
  • Price$30
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging25mg
  • Price$49
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging50mg
  • Price$79
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging100mg
  • Price$114
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging250mg
  • Price$200
  • Updated2026-05-25
  • Buy
  • ManufacturerA2B
  • Product numberAX62566
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging1g
  • Price$772
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging1g
  • Price$815
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging250mg
  • Price$222
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging50mg
  • Price$87
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging100mg
  • Price$127
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging25mg
  • Price$55
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging10mg
  • Price$34
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging5mg
  • Price$24
  • Updated2026-05-30
  • Buy
  • Manufactureraablocks
  • Product numberAA01EN1M
  • Product description6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98%
  • Packaging1mg
  • Price$13
  • Updated2026-05-30
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 1mg $12 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 5mg $22 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 10mg $30 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 25mg $49 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 50mg $79 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 100mg $114 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 250mg $200 2026-05-25 Buy
A2B AX62566 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 1g $772 2026-05-25 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 1g $815 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 250mg $222 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 50mg $87 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 100mg $127 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 25mg $55 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 10mg $34 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 5mg $24 2026-05-30 Buy
aablocks AA01EN1M 6-[(1-acetylpiperidin-4-yl)amino]-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyrimidine-4-carboxamide 98% 1mg $13 2026-05-30 Buy
Next Last

Properties

Boiling point :760.3±60.0 °C(Predicted)
Density :1.275±0.06 g/cm3(Predicted)
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :Soluble in DMSO (up to 20 mg/ml).
pka :12.44±0.46(Predicted)
form :solid
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :JLCCNYVTIWRPIZ-NRFANRHFSA-N
SMILES :C1=NC(NC2CCN(C(C)=O)CC2)=CC(C(NC[C@H](O)CN2CCC3=C(C2)C=CC=C3)=O)=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

GSK3326595 (1616395-22-3) is a potent (IC50= 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1PRMT5 inhibition activated the p53 pathwayviainduction of alternative splicing of MDM4 leading to a potent anti-proliferative response bothin vitroandin vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2Currently in clinical trials.3

More related product prices

2-(2-Methoxyethoxy)ethanol GSK-2881078 GSK2636771 MethanesulfonaMide, N-[5-[4-[5-[[(2R,6S)-2,6-diMethyl-4-Morpholinyl]Methyl]-2-oxazolyl]-1H-indazol-6-yl]-2-Methoxy-3-pyridinyl]-, rel- GSK2982772 GSK-2256098 188591-46-0 GSK481 GSK461364 GSK583 GSK484 1346572-63-1 RET Kinase inhibitor 1

Related product price

Suppliers and manufacturers

Dezhou LonWel Pharmaceutical Technology Co., Ltd. Deyang Sino Biotech. Co., LTD Beijing HwrkChemical Technology Co., Ltd Shanghai Topbiochem Technology Co., Ltd ShangHai Caerulum Pharma Discovery Co., Ltd. Bide Pharmatech Ltd. AdooQ Bioscience CHINA Shanghai YuanQi Biotechnology Co., Ltd. Shanghai Lollane Biological Technology Co.,Ltd. Shanghaizehan biopharma technology co., Ltd.