NUTLIN-3
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- $35.24 - $2245.7
- Product name: NUTLIN-3
- CAS: 548472-68-0
- MF: C30H30Cl2N4O4
- MW: 581.49
- EINECS:200-258-5
- MDL Number:MFCD07784509
- Synonyms:(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE;NUTLIN-3;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one;Nutlin-3, >=98%;NUTLIN-3 (Free base)
64 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Iris Biotech GmbH
- Matrix Scientific
- Sigma-Aldrich
- Synthonix
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 2x5mg
- 50
- 1MG
- 5.00mg
- 10MG
- 10.00mg
- 25mg
- 50.00mg
- 50mg
- 0.1g
- 100mg
- 0.25g
- 250mg
- 1g
- 10
- 5g
- ManufacturerAK Scientific
- Product number1959AH
- Product descriptionNutlin-3
- Packaging25mg
- Price$248
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008268
- Product descriptionNUTLIN-3 95.00%
- Packaging1MG
- Price$579.69
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008268
- Product descriptionNUTLIN-3 95.00%
- Packaging10MG
- Price$817.39
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6058
- Product description(±)-Nutlin-3
- Packaging50mg
- Price$328
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6058
- Product description(±)-Nutlin-3
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6058
- Product description(±)-Nutlin-3
- Packaging10mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6058
- Product description(±)-Nutlin-3
- Packaging5mg
- Price$72
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB6058
- Product description(±)-Nutlin-3
- Packaging5mg
- Price$106
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6058
- Product description(±)-Nutlin-3
- Packaging10mg
- Price$121
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSY291283
- Product description4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98%
- Packaging0.1g
- Price$153
- Updated2026-05-25
- Buy
- ManufacturerArctom
- Product numberSY291283
- Product description4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98%
- Packaging0.25g
- Price$255
- Updated2026-05-25
- Buy
- ManufacturerArctom
- Product numberSY291283
- Product description4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98%
- Packaging1g
- Price$697
- Updated2026-05-25
- Buy
- ManufacturerArctom
- Product numberSY291283
- Product description4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98%
- Packaging5g
- Price$1615
- Updated2026-05-25
- Buy
- ManufacturerAvaChem
- Product number6615
- Product descriptionNutlin-3 98%
- Packaging25mg
- Price$400
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number6615
- Product descriptionNutlin-3 98%
- Packaging5mg
- Price$100
- Updated2026-05-22
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1585
- Product descriptionNutlin-3
- Packaging5mg
- Price$104.5
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1959AH | Nutlin-3 | 25mg | $248 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008268 | NUTLIN-3 95.00% | 1MG | $579.69 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008268 | NUTLIN-3 95.00% | 10MG | $817.39 | 2021-12-16 | Buy |
| ApexBio Technology | B6058 | (±)-Nutlin-3 | 50mg | $328 | 2026-05-06 | Buy |
| ApexBio Technology | B6058 | (±)-Nutlin-3 | 50mg | $540 | 2021-12-16 | Buy |
| ApexBio Technology | B6058 | (±)-Nutlin-3 | 10mg | $156 | 2021-12-16 | Buy |
| ApexBio Technology | B6058 | (±)-Nutlin-3 | 5mg | $72 | 2026-05-06 | Buy |
| ApexBio Technology | B6058 | (±)-Nutlin-3 | 5mg | $106 | 2021-12-16 | Buy |
| ApexBio Technology | B6058 | (±)-Nutlin-3 | 10mg | $121 | 2026-05-06 | Buy |
| Arctom | SY291283 | 4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98% | 0.1g | $153 | 2026-05-25 | Buy |
| Arctom | SY291283 | 4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98% | 0.25g | $255 | 2026-05-25 | Buy |
| Arctom | SY291283 | 4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98% | 1g | $697 | 2026-05-25 | Buy |
| Arctom | SY291283 | 4-[cis-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one >98% | 5g | $1615 | 2026-05-25 | Buy |
| AvaChem | 6615 | Nutlin-3 98% | 25mg | $400 | 2026-05-22 | Buy |
| AvaChem | 6615 | Nutlin-3 98% | 5mg | $100 | 2026-05-22 | Buy |
| Axon Medchem | Axon1585 | Nutlin-3 | 5mg | $104.5 | 2026-05-19 | Buy |
Properties
Melting point :>132oC (dec.)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :solid
pka :14.35±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :BDUHCSBCVGXTJM-UHFFFAOYSA-N
SMILES :N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |&1:20,28,r|
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :solid
pka :14.35±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :BDUHCSBCVGXTJM-UHFFFAOYSA-N
SMILES :N1CCN(C(N2C(C3=CC=C(OC)C=C3OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]2C2=CC=C(Cl)C=C2)=O)CC1=O |&1:20,28,r|
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
(+)-Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction.3 (+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-Mdm2 interaction than ()-nutlin-3, demonstrating an IC50 value of 13.6 M. This inactive enantiomer can serve as a useful control for non-MDM2 related cellular activities.Related product price
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