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ChemicalBook >> CAS DataBase List >> PD 184161

PD 184161

PD 184161 price.
  • $31 - $2100
  • Product name: PD 184161
  • CAS: 212631-67-9
  • MF: C17H13BrClF2IN2O2
  • MW: 557.56
  • EINECS:
  • MDL Number:MFCD16038897
  • Synonyms:PD 184161;PF-1529483;PF-3011370;UK-287074;MEK1/2 Inhibitor IV ;5-BroMo-2-[(2-chloro-4-iodophenyl)aMino]-N-(cyclopropylMethoxy)-3,4-difluorobenzaMide;MEK1/2 Inhibitor IV - CAS 212631-67-9 - Calbiochem;Benzamide, 5-bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluoro-
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  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Biosynth
  • Cayman Chemical
  • ChemScene
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  • TRC
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging2mg
  • Price$56
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging5mg
  • Price$78
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide ≥98%
  • Packaging1mg
  • Price$31
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging10mg
  • Price$123
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging25mg
  • Price$250
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging50mg
  • Price$403
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging100mg
  • Price$571
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging200mg
  • Price$810
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA006XZ9
  • Product description5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide
  • Packaging500mg
  • Price$1204
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberT91803
  • Product descriptionPD 184161 98%
  • Packaging100MG
  • Price$530
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberT91803
  • Product descriptionPD 184161 98%
  • Packaging25MG
  • Price$205
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number3775BB
  • Product description5-Bromo-2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
  • Packaging1mg
  • Price$128
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4361
  • Product descriptionPD 184161
  • Packaging5mg
  • Price$115
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4361
  • Product descriptionPD 184161
  • Packaging10mg
  • Price$205
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4361
  • Product descriptionPD 184161
  • Packaging25mg
  • Price$450
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberHY-10174
  • Product descriptionPD184161 98.08%
  • Packaging50mg
  • Price$551
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 2mg $56 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 5mg $78 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide ≥98% 1mg $31 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 10mg $123 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 25mg $250 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 50mg $403 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 100mg $571 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 200mg $810 2026-05-28 Buy
aablocks AA006XZ9 5-Bromo-2-((2-Chloro-4-Iodophenyl)Amino)-N-(Cyclopropylmethoxy)-3,4-Difluorobenzamide 500mg $1204 2026-05-28 Buy
ACHEMBLOCK T91803 PD 184161 98% 100MG $530 2026-05-27 Buy
ACHEMBLOCK T91803 PD 184161 98% 25MG $205 2026-05-27 Buy
AK Scientific 3775BB 5-Bromo-2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide 1mg $128 2021-12-16 Buy
ApexBio Technology C4361 PD 184161 5mg $115 2026-05-06 Buy
ApexBio Technology C4361 PD 184161 10mg $205 2026-05-06 Buy
ApexBio Technology C4361 PD 184161 25mg $450 2026-05-06 Buy
Arctom HY-10174 PD184161 98.08% 50mg $551 2026-05-26 Buy

Properties

Melting point :174-175 °C
Density :1.922±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :White solid
pka :-6.25±0.50(Predicted)
color :white to off-white
InChI :1S/C17H13BrClF2IN2O2/c18-11-6-10(17(25)24-26-7-8-1-2-8)16(15(21)14(11)20)23-13-4-3-9(22)5-12(13)19/h3-6,8,23H,1-2,7H2,(H,24,25)
InChIKey :VJNZMSLGVUSPCF-UHFFFAOYSA-N
SMILES :Ic1cc(c(cc1)Nc2c(c(c(cc2C(=O)NOCC3CC3)Br)F)F)Cl

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

PD 184161 is a strong and selective inhibitor of MEK-1 and MEK-2 with an IC50 value that ranges from 10-100 nM. 1 More effective at inhibiting phosphorylation of ERK1/2 than the selective MEK inhibitors, PD098059 and U0126. PD 184161 is structurally related to clinically-studied MEK inhibitors PD184352 (CI-1040) and PD 325901 and has been shown to inhibit cell proliferation, induce apoptosis, and possess anti-tumor activity in MEK-dependent cancers.

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