PFI-2 (hydrochloride)
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- $33 - $1582
- Product name: PFI-2 (hydrochloride)
- CAS: 1627607-87-7
- MF: C23H26ClF4N3O3S
- MW: 535.98
- EINECS:
- MDL Number:MFCD28133380
- Synonyms:PFI-2 (hydrochloride);PFI-2 HCl salt;(R)-PFI-2 (hydrochloride);(R)-PFI-2;PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2;(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride;(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride;macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride
25 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 2.5mg
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2944AH
- Product description(R)-PFI2hydrochloride
- Packaging1mg
- Price$152
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA382439
- Product description(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamidehydrochloride 98+%
- Packaging5mg
- Price$151
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA382439
- Product description(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamidehydrochloride 98+%
- Packaging10mg
- Price$227
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA382439
- Product description(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamidehydrochloride 98+%
- Packaging50mg
- Price$613
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB8210
- Product descriptionPFI-2(hydrochloride)
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging1mg
- Price$33
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging10mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging50mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging100mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging250mg
- Price$634
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS540296
- Product descriptionPFI-2hydrochloride ≥98%
- Packaging1g
- Price$1582
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14678
- Product description(R)-PFI-2 (hydrochloride) ≥95%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14678
- Product description(R)-PFI-2 (hydrochloride) ≥95%
- Packaging5mg
- Price$179
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14678
- Product description(R)-PFI-2 (hydrochloride) ≥95%
- Packaging10mg
- Price$330
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14678
- Product description(R)-PFI-2 (hydrochloride) ≥95%
- Packaging25mg
- Price$751
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2944AH | (R)-PFI2hydrochloride | 1mg | $152 | 2021-12-16 | Buy |
| Ambeed | A382439 | (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamidehydrochloride 98+% | 5mg | $151 | 2021-12-16 | Buy |
| Ambeed | A382439 | (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamidehydrochloride 98+% | 10mg | $227 | 2021-12-16 | Buy |
| Ambeed | A382439 | (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamidehydrochloride 98+% | 50mg | $613 | 2021-12-16 | Buy |
| ApexBio Technology | B8210 | PFI-2(hydrochloride) | 25mg | $250 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 1mg | $33 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 5mg | $80 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 10mg | $130 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 50mg | $220 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 100mg | $320 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 250mg | $634 | 2021-12-16 | Buy |
| Arctom | AS540296 | PFI-2hydrochloride ≥98% | 1g | $1582 | 2021-12-16 | Buy |
| Cayman Chemical | 14678 | (R)-PFI-2 (hydrochloride) ≥95% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 14678 | (R)-PFI-2 (hydrochloride) ≥95% | 5mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 14678 | (R)-PFI-2 (hydrochloride) ≥95% | 10mg | $330 | 2024-03-01 | Buy |
| Cayman Chemical | 14678 | (R)-PFI-2 (hydrochloride) ≥95% | 25mg | $751 | 2024-03-01 | Buy |
Properties
Melting point :>209°C (dec.)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :ZADKZNVAJGEFLC-GKNLIIIVNA-N
SMILES :FC1C=C(S(=O)(=O)N[C@@H](C(N2CCCC2)=O)CC2C=CC=C(C(F)(F)F)C=2)C=C2CCNCC=12.Cl |&1:8,r|
storage temp. :2-8°C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey :ZADKZNVAJGEFLC-GKNLIIIVNA-N
SMILES :FC1C=C(S(=O)(=O)N[C@@H](C(N2CCCC2)=O)CC2C=CC=C(C(F)(F)F)C=2)C=C2CCNCC=12.Cl |&1:8,r|
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. Its enantiomer, (S)-PFI-2 , is 500-fold less active (IC50 = 1 μM). See the Structural Genomics Consortium (SGC) website for more information.More related product prices
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