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ChemicalBook >> CAS DataBase List >> Rhein

Rhein

$5 - $2120
Product name: Rhein
CAS: 478-43-3
MF: C15H8O6
MW: 284.22
EINECS:207-521-4
MDL Number:MFCD00009618
Synonyms:chrysazin-3-carboxylicacid ;monorhein ;rheicacid ;RHUBARB YELLOW;RHEIN;TIMTEC-BB SBB001152;1,8-DIHYDROXY-9,10-ANTHRAQUINONE-3-CARBOXYLIC ACID;1,8-DIHYDROXYANTHRAQUINONE-3-CARBOXYLIC ACID

Price82 Properties Safety Information Description

82 prices

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aablocks
ACHEMBLOCK
AK Scientific
Ambeed
American Custom Chemicals Corporation
ApexBio Technology
Arctom
AvaChem
Biorbyt Ltd
Biosynth
Cayman Chemical
Chemenu
Chem-Impex
ChemScene
Chemtos
Crysdot
DC Chemicals
JR MediChem
Matrix Scientific
Medical Isotopes, Inc.
Sigma-Aldrich
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Thermo Scientific Chemicals
Tocris
TRC
Usbiological

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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%
Packaging50mg
Price$10
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging100mg
Price$11
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%
Packaging250mg
Price$11
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging1g
Price$15
Updated2026-05-28
Buy

Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging5g
Price$33
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging25g
Price$102
Updated2026-05-28
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Manufactureraablocks
Product numberAA0037CJ
Product description1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%
Packaging100g
Price$359
Updated2026-05-28
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ManufacturerACHEMBLOCK
Product numberX191876
Product description4,5-Dihydroxyanthraquinone-2-carboxylic acid 95.00%
Packaging25G
Price$105
Updated2026-05-27
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ManufacturerAK Scientific
Product numberC432
Product descriptionRhein
Packaging1g
Price$364
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging25mg
Price$5
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging100mg
Price$6
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging250mg
Price$9
Updated2021-12-16
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ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging1g
Price$19
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging5g
Price$58
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging25g
Price$188
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA105483
Product description4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%
Packaging100g
Price$548
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%	50mg	$10	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	100mg	$11	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE ≥98%	250mg	$11	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	1g	$15	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	5g	$33	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	25g	$102	2026-05-28	Buy
aablocks	AA0037CJ	1,8-DIHYDROXY-3-CARBOXYANTHRAQUINONE 98+%	100g	$359	2026-05-28	Buy
ACHEMBLOCK	X191876	4,5-Dihydroxyanthraquinone-2-carboxylic acid 95.00%	25G	$105	2026-05-27	Buy
AK Scientific	C432	Rhein	1g	$364	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	25mg	$5	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	100mg	$6	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	250mg	$9	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	1g	$19	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	5g	$58	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	25g	$188	2021-12-16	Buy
Ambeed	A105483	4,5-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylicacid 98+%	100g	$548	2021-12-16	Buy

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Properties

Melting point :≥300 °C (lit.)
Boiling point :346.72°C (rough estimate)
Density :1.3269 (rough estimate)
refractive index :1.4413 (estimate)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :3.17±0.20(Predicted)
color :Yellow to Dark Orange
Water Solubility :<0.1 g/100 mL at 17 ºC
λmax :432nm(MeOH)(lit.)
Merck :14,8176
BRN :2222155
Stability :Hygroscopic
Cosmetics Ingredients Functions :ANTIMICROBIAL
InChI :1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
InChIKey :FCDLCPWAQCPTKC-UHFFFAOYSA-N
SMILES :OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
LogP :4.290 (est)
CAS DataBase Reference :478-43-3(CAS DataBase Reference)
EPA Substance Registry System :2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (478-43-3)

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13. It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression. Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis. It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.

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Suppliers and manufacturers

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Rhein

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