Riociguat
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- $7 - $2660
- Product name: Riociguat
- CAS: 625115-55-1
- MF: C20H19FN8O2
- MW: 422.42
- EINECS:641-755-1
- MDL Number:MFCD19443708
- Synonyms:Riociguat;Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-B)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester;Riociguat (BAY 63-2521);Riocguat;CS-718;Riociguat, BZY 632521;BAY 63-2521; BAY 632521;Riociguat IMpurtiy D
101 prices
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Brand
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 250.00mg
- 500mg
- 1.00g
- 1g
- 1000mg
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- 5.00g
- 5g
- 10g
- 25g
- 50G
- 10mM*1mLinDMSO
- 100G
- 15 mg
- 10mM(1mLinDMSO)
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging1mg
- Price$11
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging5mg
- Price$14
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging10mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging50mg
- Price$24
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging100mg
- Price$31
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging250mg
- Price$48
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95%
- Packaging1g
- Price$115
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 98%
- Packaging5g
- Price$340
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 98%
- Packaging10g
- Price$607
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ECBT
- Product descriptionMethyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 98%
- Packaging25g
- Price$1342
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging50G
- Price$2340
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99%
- Packaging50G
- Price$2340
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging100G
- Price$2660
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging100G
- Price$2660
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging25G
- Price$820
- Updated2021-12-16
- Buy
- ManufacturerAccelPharmtech
- Product numberXP2357
- Product descriptionRiociguat 99.00%
- Packaging25G
- Price$820
- Updated2026-05-21
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 1mg | $11 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 5mg | $14 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 10mg | $17 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 50mg | $24 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 100mg | $31 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 250mg | $48 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 95% | 1g | $115 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 98% | 5g | $340 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 98% | 10g | $607 | 2026-05-28 | Buy |
| aablocks | AA00ECBT | Methyl (4,6-diaMino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyriMidin-5-yl)(Methyl)carbaMate 98% | 25g | $1342 | 2026-05-28 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 50G | $2340 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99% | 50G | $2340 | 2026-05-21 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 100G | $2660 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 100G | $2660 | 2026-05-21 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 25G | $820 | 2021-12-16 | Buy |
| AccelPharmtech | XP2357 | Riociguat 99.00% | 25G | $820 | 2026-05-21 | Buy |
Properties
Melting point :247-251°C (dec.)
Boiling point :567.2±50.0 °C(Predicted)
Density :1.51
storage temp. :Refrigerator
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :1.51±0.50(Predicted)
form :Solid
color :Off-White to Orange
InChI :InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
InChIKey :WXXSNCNJFUAIDG-UHFFFAOYSA-N
SMILES :C(OC)(=O)N(C1=C(N)N=C(C2C3=CC=CN=C3N(CC3=CC=CC=C3F)N=2)N=C1N)C
Boiling point :567.2±50.0 °C(Predicted)
Density :1.51
storage temp. :Refrigerator
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :1.51±0.50(Predicted)
form :Solid
color :Off-White to Orange
InChI :InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
InChIKey :WXXSNCNJFUAIDG-UHFFFAOYSA-N
SMILES :C(OC)(=O)N(C1=C(N)N=C(C2C3=CC=CN=C3N(CC3=CC=CC=C3F)N=2)N=C1N)C
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Riociguat is a first-in-class oral medication that adds to the treatment options for PAH. In September 2013, Health Canada approved riociguat (also referred to as BAY 63-2521), for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) after surgical treatment or inoperable CTEPH and for the treatment of adults with pulmonary arterial hypertension (PAH). Riociguat has a dual mode of action and works by (a) sensitizing sGC to the body's NO by stabilizing NO–sGC binding and (b) an NO-independent, direct stimulation of sGC via a different binding site. This process restores the NO–sGC–cGMP pathway and leads to increased generation of cGMP with subsequent vasodilation.Headache, dizziness, dyspepsia/gastritis, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation were the most common adverse events ( 3%) observed during riociguat clinical trials. Riociguat comes with a black box warning for embryo-fetal toxicity.
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