TG6-129
|
- $44 - $478
- Product name: TG6-129
- CAS: 1164464-14-5
- MF: C20H18FN5O3S3
- MW: 491.58
- EINECS:
- MDL Number:
- Synonyms:TG6-129;(E)-N-(4-(N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamoyl)carbamothioyl)-3-(4-fluorophenyl)acrylamide;TG6-129,TG6129,inhibit,Prostaglandin Receptor,Inhibitor,TG-6-129;2-Propenamide, N-[[[4-[[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]sulfonyl]phenyl]amino]thioxomethyl]-3-(4-fluorophenyl)-, (2E)-;TG6-129, 10 mM in DMSO
6 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
Package
- 500μg
- 1mg
- 5mg
- 25mg
- ManufacturerAK Scientific
- Product number4658CG
- Product descriptionCID1987175
- Packaging1mg
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number4658CG
- Product descriptionCID1987175
- Packaging5mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19085
- Product descriptionTG6-129 ≥98%
- Packaging500μg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19085
- Product descriptionTG6-129 ≥98%
- Packaging1mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19085
- Product descriptionTG6-129 ≥98%
- Packaging5mg
- Price$341
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberT337945
- Product descriptionTG6-129
- Packaging25mg
- Price$340
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4658CG | CID1987175 | 1mg | $185 | 2021-12-16 | Buy |
| AK Scientific | 4658CG | CID1987175 | 5mg | $478 | 2021-12-16 | Buy |
| Cayman Chemical | 19085 | TG6-129 ≥98% | 500μg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 19085 | TG6-129 ≥98% | 1mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 19085 | TG6-129 ≥98% | 5mg | $341 | 2024-03-01 | Buy |
| TRC | T337945 | TG6-129 | 25mg | $340 | 2021-12-16 | Buy |
Properties
Density :1.518±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 8 mg/ml; DMSO: 10 mg/ml
form :A crystalline solid
pka :5.24±0.50(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 8 mg/ml; DMSO: 10 mg/ml
form :A crystalline solid
pka :5.24±0.50(Predicted)
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Prostaglandin E2 (PGE2; ) evokes distinct responses through four different ‘E prostanoid’ (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. It is without effect on EP4, DP1, IP, and β2-adrenergic receptors. TG6-129 reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. It has low cell cytotoxicity (CC50 = 326 μM), prolonged plasma half-life, and does not cross the blood-brain barrier.Related product price
- TG4-155
$62-5328 - 51987-99-6
$95-2395.3
Suppliers and manufacturers
TargetMol Chemicals Inc.
BOC Sciences
Shanghai EFE Biological Technology Co., Ltd.
Shanghai Hongye Biotechnology Co. Ltd
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Energy Chemical
MedBioPharmaceutical Technology Inc
TargetMol Chemicals Inc.
Suzhou Zhixin Biotechnology Co., Ltd.
