Tucatinib
|
- $9 - $2500
- Product name: Tucatinib
- CAS: 937263-43-9
- MF: C26H24N8O2
- MW: 480.52
- EINECS:200-001-8
- MDL Number:MFCD22380467
- Synonyms:ONT-380);N4-(4-([1;4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-;N6-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4,6-quinazolinediamine;Irbinitinib(ARRY380);Irbinitinib (ARRY-380,Tucatinib,ONT 380);IRBINITINIB (ARRY-380; ONT-380);(R)-N6-(4-Methyl-4
38 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- AvaChem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
- Usbiological
Package
- 2.5mg
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100.00mg
- 100mg
- 250mg
- 250.00mg
- 500mg
- 1.00g
- 1g
- 5g
- 10g
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging1mg
- Price$9
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging10mg
- Price$18
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging25mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging100mg
- Price$63
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging250mg
- Price$106
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging1g
- Price$286
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00GTX3
- Product description4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98%
- Packaging5g
- Price$998
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22591
- Product descriptionIrbinitinib 98%
- Packaging5G
- Price$1050
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22591
- Product descriptionIrbinitinib 98%
- Packaging1G
- Price$320
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM22591
- Product descriptionIrbinitinib 98%
- Packaging100MG
- Price$70
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8979DH
- Product descriptionTucatinib
- Packaging25mg
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number5201
- Product descriptionTucatinib; Irbinitinib 99%
- Packaging5mg
- Price$55
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number5201
- Product descriptionTucatinib; Irbinitinib 99%
- Packaging25mg
- Price$145
- Updated2026-05-22
- Buy
- ManufacturerAvaChem
- Product number5201
- Product descriptionTucatinib; Irbinitinib 99%
- Packaging10mg
- Price$85
- Updated2026-05-22
- Buy
- ManufacturerBiosynth
- Product numberBT177688
- Product descriptionTucatinib
- Packaging100mg
- Price$1125
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberBT177688
- Product descriptionTucatinib
- Packaging25mg
- Price$375
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 1mg | $9 | 2026-05-28 | Buy |
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 10mg | $18 | 2026-05-28 | Buy |
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 25mg | $27 | 2026-05-28 | Buy |
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 100mg | $63 | 2026-05-28 | Buy |
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 250mg | $106 | 2026-05-28 | Buy |
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 1g | $286 | 2026-05-28 | Buy |
| aablocks | AA00GTX3 | 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- 98% | 5g | $998 | 2026-05-28 | Buy |
| ACHEMBLOCK | M22591 | Irbinitinib 98% | 5G | $1050 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22591 | Irbinitinib 98% | 1G | $320 | 2026-05-27 | Buy |
| ACHEMBLOCK | M22591 | Irbinitinib 98% | 100MG | $70 | 2026-05-27 | Buy |
| AK Scientific | 8979DH | Tucatinib | 25mg | $590 | 2021-12-16 | Buy |
| AvaChem | 5201 | Tucatinib; Irbinitinib 99% | 5mg | $55 | 2026-05-22 | Buy |
| AvaChem | 5201 | Tucatinib; Irbinitinib 99% | 25mg | $145 | 2026-05-22 | Buy |
| AvaChem | 5201 | Tucatinib; Irbinitinib 99% | 10mg | $85 | 2026-05-22 | Buy |
| Biosynth | BT177688 | Tucatinib | 100mg | $1125 | 2026-06-04 | Buy |
| Biosynth | BT177688 | Tucatinib | 25mg | $375 | 2026-06-04 | Buy |
Properties
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
DMSO:49.0(Max Conc. mg/mL);101.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM) form :A crystalline solid
pka :6.61±0.70(Predicted)
color :White to yellow
InChIKey :SDEAXTCZPQIFQM-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(NC3=NC(C)(C)CO3)C=C2)=C(NC2=CC=C(OC3C=CN4N=CN=C4C=3)C(C)=C2)N=C1
storage temp. :Store at -20°C
solubility :DMF:1.0(Max Conc. mg/mL);2.08(Max Conc. mM)
DMSO:49.0(Max Conc. mg/mL);101.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.69(Max Conc. mM) form :A crystalline solid
pka :6.61±0.70(Predicted)
color :White to yellow
InChIKey :SDEAXTCZPQIFQM-UHFFFAOYSA-N
SMILES :N1=C2C(C=C(NC3=NC(C)(C)CO3)C=C2)=C(NC2=CC=C(OC3C=CN4N=CN=C4C=3)C(C)=C2)N=C1
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Tucatinib is also known as ARRY-380 or Irbinitinib. ARRY-380 is an orally inhibitor of human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. It selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. Therefore, ARRY-380 may be an alternative treatmentmethod for the treatment of HER2+ cancers.More related product prices
AZD-9291 Dacomitinib (PF299804) CO-1686 Poziotinib (HM781-36B) Neratinib EGF816 OSI-420 AG 1478 HYDROCHLORIDE AZD 3759 Genistein Olmutinib Everolimus Anastrozole XL-647 TroxerutinRelated product price
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AZD-9291
$4-1800 -
Dacomitinib (PF299804)
$10-1703 -
CO-1686
$9-3510
Suppliers and manufacturers
Zhengzhou Anbu Chem Co.,Ltd
Irbinitinib
CAS:937263-43-9
Hangzhou Hyper Chemicals Limited
Tucatinib
CAS:937263-43-9
Zison Pharmaceutical (Shandong) Co., Ltd.
Suzhou ARTK Medchem Co., Ltd.
Henan Tianfu Chemical Co.,Ltd.
Shenzhen Nexconn Pharmatechs Ltd
CONIER CHEM AND PHARMA LIMITED
Suzhou Ryan Pharmachem Technology Co.,Ltd.
Tucatinib
CAS:937263-43-9
