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ChemicalBook CAS DataBase List 1-Prop-2-ynyl-cyclohexanecarbonitrile
850011-76-6

1-Prop-2-ynyl-cyclohexanecarbonitrile synthesis

5synthesis methods
Cyclohexanecarbonitrile, 1-(phenylsulfinyl)-

1360557-39-6
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1-Prop-2-ynyl-cyclohexanecarbonitrile

850011-76-6
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Yield:850011-76-6 86%

Reaction Conditions:

Stage #1: 1-(phenylsulfinyl)cyclohexanecarbonitrilewith isopropylmagnesium chloride in tetrahydrofuran at -78; for 0.0833333 h;
Stage #2: propargyl bromide in tetrahydrofuran at 20; for 2 h;

References:

Nath, Dinesh;Fleming, Fraser F. [Chemistry - A European Journal,2013,vol. 19,# 6,p. 2023 - 2029] Location in patent:supporting information

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