Cyclohexanecarboxylic acid, 4-[bis(phenylmethyl)amino]-, trans- synthesis
- Product Name:Cyclohexanecarboxylic acid, 4-[bis(phenylmethyl)amino]-, trans-
- CAS Number:102390-36-3
- Molecular formula:C21H25NO2
- Molecular Weight:323.43
![Cyclohexanecarboxylic acid, 4-[bis(phenylmethyl)amino]-, ethyl ester, trans-](/CAS/20180527/GIF/219770-57-7.gif)
219770-57-7
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Yield:102390-36-3 81.5%
Reaction Conditions:
with water;sodium hydroxide in methanol at 20; for 1 h;
Steps:
192a.2; 192b.2 Step 2:
(1r,4r)-4-(dibenzylamino)cyclohexane-1-carboxylic acid
A solution of ethyl (1r,4r)-4-(dibenzylamino)cyclohexane-1-carboxylate (3.60 g, 10.24 mmol, 1 equiv), NaOH (0.82 g, 20.5 mmol, 2 equiv), H2O (15 mL) in MeOH (60 mL) was stirred for 1 h at RT.
The pH value of the solution was adjusted to 6 with HCl (0.1 M).
Then solids were collected by filtration and dried to afford the title compound (2.7 g, 81.5%) as a white solid. LCMS: [M+H]+ 324.15.
References:
US2021/32251,2021,A1 Location in patent:Paragraph 0805
100-39-0
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