2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-phenyl- synthesis
1synthesis methods
- Product Name:2,4,6(1H,3H,5H)-Pyrimidinetrione, 1-methyl-5-phenyl-
- CAS Number:103858-65-7
- Molecular formula:C11H10N2O3
- Molecular Weight:218.21
Yield:103858-65-7 54%
Reaction Conditions:
Stage #1: diethyl 2-phenylmalonate;N-Methylureawith sodium methylate in ethanol; for 3.5 h;Reflux;
Stage #2: with hydrogenchloride in ethanol;water at 22 - 25;
References:
Bolz, Ina;Spange, Stefan;Schaarschmidt, Dieter;Rueffer, Tobias;Lang, Heinrich [Angewandte Chemie - International Edition,2009,vol. 48,# 40,p. 7440 - 7443][Angewandte Chemie,2009,vol. 121,# 40,p. 7576 - 7579] Location in patent:supporting information; experimental part