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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 3-(6-Bromopyridin-2-yl)-6-chloroimidazo[1,2-a]pyridine
1044733-65-4

3-(6-Bromopyridin-2-yl)-6-chloroimidazo[1,2-a]pyridine synthesis

1synthesis methods
626-05-1 Synthesis
2,6-Dibromopyridine

626-05-1
486 suppliers
$9.00/10g

885275-59-2 Synthesis
6-Chloro-3-iodo-imidazo[1,2-a]pyridine

885275-59-2
71 suppliers
$41.00/250mg

3-(6-Bromopyridin-2-yl)-6-chloroimidazo[1,2-a]pyridine

1044733-65-4
33 suppliers
$78.00/100mg

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Yield:-

Reaction Conditions:

Stage #1:6-chloro-3-iodoimidazo[1,2-a]pyridine with isopropylmagnesium chloride in tetrahydrofuran at -78;Grignard reaction;
Stage #2: with tributyltin chloride in tetrahydrofuran at -78 - 20;
Stage #3:2,6-Dibromopyridine with tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran at 140;Microwave irradiation;Stille coupling;

References:

Buckley, George M.;Fosbeary, Richard;Fraser, Joanne L.;Gowers, Lewis;Higueruelo, Alicia P.;James, Lynwen A.;Jenkins, Kerry;Mack, Stephen R.;Morgan, Trevor;Parry, David M.;Pitt, William R.;Rausch, Oliver;Richard, Marianna D.;Sabin, Verity [Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,# 12,p. 3656 - 3660] Location in patent:scheme or table

3-(6-Bromopyridin-2-yl)-6-chloroimidazo[1,2-a]pyridine Related Search:

2-(4-Bromophenyl)-6-chloroimidazo[1,2-a]pyridine 6-Chloro-2-(4-chlorophenyl)imidazo[1,2-α]pyridine Imidazo[1,2-a]pyridine, 3-(6-chloro-2-pyrazinyl)- 2-(4-BroMophenyl)-6,8-dichloroiMidazo[1,2-a]pyridine