tert-butyl 8-bromo-5-methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate synthesis
- Product Name:tert-butyl 8-bromo-5-methyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate
- CAS Number:1173155-41-3
- Molecular formula:C17H21BrN2O2
- Molecular Weight:365.26
![tert-butyl 8-bromo-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate](/CAS/GIF/1234685-60-9.gif)
Yield:-
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide at 20;
Steps:
13.b
To a solution of tert-butyl 8-bromo-3,4-dihydro-lH-pyrido[4,3-δ]indole-2(5H)- carboxylate (0.53g, 1.5 mmol) in DMF (6 mL) was added NaH (60% weight dispersion in mineral oil, 91 mg, 2.3 mmol) and CH3I (0.14 mL, 2.3 mmol). The reaction mixture was stirred at room temperature until the reaction was complete. Then the reaction was quenched with H2O and extracted with CH2Cl2. The organic layer was washed with H2O and 5% LiCl, dried WkIi Na2SO4, filtered and concentrated to give tert-butyl 8-bromo-5- methyl-3,4-dihydro-lH-pyrido[4,3-δ]indole-2(5H)-carboxylate, which was used directly without purification.
References:
WO2009/89482,2009,A1 Location in patent:Page/Page column 60
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