2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid synthesis
- Product Name:2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-carboxylic acid
- CAS Number:1211443-58-1
- Molecular formula:C12H12ClN3O2
- Molecular Weight:265.7
1211443-55-8
1211443-58-1
2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxaldehyde (2.69 g, 11 mmol) was used as starting material and dissolved in DMF. Subsequently, Oxone (7.2 g, 12 mmol) was added to this solution and the reaction was stirred at room temperature for 6 hours. After completion of the reaction, water was added to the reaction mixture to precipitate the target product. The yellow solid, 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid (2.69 g, 85% yield) was collected by filtration. Mass spectrum (ESI) m/z 266 [M + H]+.
1211443-55-8
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1211443-58-1
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Yield:1211443-58-1 85%
Reaction Conditions:
with oxone in N,N-dimethyl-formamide; for 6 h;
Steps:
F
A mixture of 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (2.69 g, 11 mmol) in DMF is added oxone (7.2 g, 12 mmol) and stirred for 6 h. After the reaction is complete, water is added and a yellow solid is precipitated to give 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3- d]pyrimidine-6-carboxylic acid (2.69 g, 85%). MS(ESI) m/z 266 A (M+H)+
References:
WO2010/20675,2010,A1 Location in patent:Page/Page column 91
733039-20-8
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1211443-58-1
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1003-03-8
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1374639-76-5
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![(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol](/CAS/20150408/GIF/1374639-77-6.gif)
1374639-77-6
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1211443-58-1
137 suppliers
$23.00/100mg