10,11-dihydro-[1,2,5]thiadiazolo[3,4-e]thieno[2',3':4,5]pyrrolo[3,2-g]thieno[3,2-b]indole synthesis

Yield:1335290-08-8 99%

Reaction Conditions:

with 1,2-dichloro-benzene;triphenylphosphine in tetrahydrofuran;water at 25; for 2 h;Reflux;Inert atmosphere;

Steps:

6 The preparation method of compound 33:

compound 32 (18.5 g, 47.3 mmol) and triphenylphosphine (99 g, 37.8 mmol) were added to a 500 mL round-bottom flask, followed by 200 mL of o-dichlorobenzene (ODCB),Heat to reflux for 12 hours under nitrogen protection.After cooling, heptane was added to produce a solid, and the solid was filtered and dried under vacuum to obtain compound 33 (15 g, yield: 99%) as a yellow solid.

References:

TWI706955,2020,B Location in patent:Paragraph 0047; 0049