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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
1346574-57-9

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide synthesis

9synthesis methods
1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL)PIPERAZINE

871125-86-9
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$65.00/500MG

1346574-54-6 Synthesis
1H-Indole-4-carboxaMide, 6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-[(1S)-1-Methylpropyl]-

1346574-54-6
21 suppliers
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S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

1346574-57-9
158 suppliers
$49.00/1mg

-

Yield:1346574-57-9 92%

Reaction Conditions:

with palladium bis[bis(diphenylphosphino)ferrocene] dichloride in water at 90;Inert atmosphere;Reagent/catalyst;

Steps:

79 synthesis of (S)-6-bromo-1-(isobutyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(p-dinitrogenhexane-2-yl)piperidin-2-yl)-1-H-indole-4-carboxamide
add (S) -6- bromo-1- (isobutyl) in 100mL three-necked flask - N - ((4,6Dimethyl-2-oxo-1,2-dihydropyridin-3-yl) methyl) -3-methyl-1 Hydrogen - indole carboxamide (365mg,0.82mmol), 2- (piperazin-1-yl) pyridine-5-boronic acid pinacol ester (309mg, 1.07mmol, 1.3eq), phosphoric acidPotassium (522mg, 2.46mmol, 3eq), water and 1,4-epoxy hexadecane solvent. Then, under a nitrogen blanketWas added [1,1'-bis (diphenylphosphino) ferrocene] dichloropalladium (II) dichloromethane complex (53.9mg,0.066 mmol), and reaction at 90 deg.] C, after purification to give the desired product 400mg (92% yield

References:

Changzhou University;Chen, Xin;Lu, Chen CN105541801, 2016, A Location in patent:Paragraph 0118

FullText

1H-Indole-4-carboxylic acid, 6-broMo-3-Methyl-1-(1-Methylpropyl)-

1346575-54-9
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S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

1346574-57-9
158 suppliers
$49.00/1mg

References
1346574-53-5 Synthesis
1H-Indole-4-carboxaMide,6-broMo-N-[(1,2-dihydro-4,6-diMethyl-2-oxo-3-pyridinyl)Methyl]-3-Methyl-1-(1-Methylpropyl)-

1346574-53-5
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S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

1346574-57-9
158 suppliers
$49.00/1mg

References
771579-27-2 Synthesis
2(1H)-Pyridinone, 3-(aminomethyl)-4,6-dimethyl- (9CI)

771579-27-2
109 suppliers
$17.00/250mg

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

1346574-57-9
158 suppliers
$49.00/1mg

References
2,5-Dibromo-3-nitro-benzoic acid

30060-12-9
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S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

1346574-57-9
158 suppliers
$49.00/1mg

References

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide Related Search:

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