(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide synthesis
- Product Name:(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
- CAS Number:1353644-70-8
- Molecular formula:C25H26N6O2
- Molecular Weight:442.51
![(3aR,6aR)-1-Methyl-hexahydropyrrolo[3,4-b]pyrrole](/CAS/20150408/GIF/1353644-77-5.gif)
1353644-77-5
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Yield:-
Reaction Conditions:
with pyridine in 1,4-dioxane at 70; for 5 h;
Steps:
3
A mixture of compound 3-c (1 g, 2.44 mmol) and compound 3-d (369 mg, 2.92 mmol) in dioxane (30mL) was stirred at 70°C for 5 hours, and then cooled to the ambient temperature. The precipitates were filtered, washed with EtOAc, and dried in vacuum to give compound 3 (0.8 g). MS (m/e):443.4(M+l)+.
References:
HUTCHISON MEDIPHARMA LIMITED;ZHANG, Weihan;SU, Wei-Guo;YANG, Haibin;CUI, Yumin;REN, Yongxin;YAN, Xiaoqiang WO2012/182, 2012, A1 Location in patent:Page/Page column 14