2,3-dihydro-1H-Isoindole-4-carbonitrile synthesis
- Product Name:2,3-dihydro-1H-Isoindole-4-carbonitrile
- CAS Number:1159883-00-7
- Molecular formula:C9H8N2
- Molecular Weight:144.17
5724-56-1
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 20 h / 80 °C
2.1: sodium carbonate / acetonitrile / 2.75 h / 80 °C / Inert atmosphere
3.1: carbonochloridic acid 1-chloro-ethyl ester / chlorobenzene / 2.75 h / 90 °C / Molecular sieve; Inert atmosphere
3.2: 1 h / Molecular sieve; Inert atmosphere; Reflux
References:
Skidmore, John;Heer, Jag;Johnson, Christopher N.;Norton, David;Redshaw, Sally;Sweeting, Jennifer;Hurst, David;Cridland, Andrew;Vesey, David;Wall, Ian;Ahmed, Mahmood;Rivers, Dean;Myatt, James;Giblin, Gerard;Philpott, Karen;Kumar, Umesh;Stevens, Alexander;Bit, Rino A.;Haynes, Andrea;Taylor, Simon;Watson, Robert;Witherington, Jason;Demont, Emmanuel;Heightman, Tom D. [Journal of Medicinal Chemistry,2014,vol. 57,# 24,p. 10424 - 10442]
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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