2-AMINO-4-BROMOBENZYL ALCOHOL synthesis
- Product Name:2-AMINO-4-BROMOBENZYL ALCOHOL
- CAS Number:946122-05-0
- Molecular formula:C7H8BrNO
- Molecular Weight:202.05
22996-19-6
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946122-05-0
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Yield:946122-05-0 90%
Reaction Conditions:
with iron;ammonium chloride in ethanol;water at 75; for 1 h;
Steps:
73.2
Step 2. A mixture of (4-bromo-2-nitro-phenyl)-methanol (1.85 g, 7.97 mmol), iron powder (2.23 g, 39.9 mmol), ammonium chloride (213 mg, 3.99 mmol), ethanol (20 mL), and water (10 mL) was heated at 75° C. for 1 h, then after cooling filtered through a pad of diatomaceous earth. The filtrate was evaporated and the residue partitioned between ethyl acetate and water, the organic layer was washed with brine, dried (MgSO4), and evaporated to produce (2-amino-4-bromo-phenyl)-methanol (1.53 g, 90%). Off-white solid, MS (EI)=201.0 (M+).
References:
Ackermann, Jean;Bleicher, Konrad;Ceccarelli, Simona M.;Chomienne, Odile;Mattei, Patrizio;Sander, Ulrike Obst US2007/191603, 2007, A1 Location in patent:Page/Page column 40
135484-83-2
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946122-05-0
70 suppliers
$24.00/250mg
20776-50-5
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946122-05-0
70 suppliers
$24.00/250mg