2-AMINO-4-FLUOROPYRIDINE synthesis
- Product Name:2-AMINO-4-FLUOROPYRIDINE
- CAS Number:944401-77-8
- Molecular formula:C5H5FN2
- Molecular Weight:112.11
19798-80-2
944401-77-8
General procedure for the synthesis of 2-amino-4-fluoropyridine from 2-amino-4-chloropyridine: 28 g of 2-amino-4-chloropyridine was dissolved in 100 ml of N,N-dimethylformamide, followed by the addition of 46 g of sodium fluoride. The reaction mixture was heated to 140°C and kept reacting for 5 to 8 hours. Upon completion of the reaction, the mixture was cooled to 80 °C and the solvent was subsequently recovered by distillation under reduced pressure. The residue was dissolved in dichloromethane and washed with saturated saline. The organic phase was separated and after evaporation of the solvent, recrystallized from ethanol to give 22 g of white solid 2-amino-4-fluoropyridine in 90% yield.
19798-80-2
538 suppliers
$6.00/1g
944401-77-8
225 suppliers
$17.00/1g
Yield:944401-77-8 90%
Reaction Conditions:
with sodium fluoride in N,N-dimethyl-formamide at 140;Solvent;Reagent/catalyst;Temperature;
Steps:
2
The 28 g 2 - amino -4 - chloro pyridine is added to the 100 ml of N, N - dimethyl formamide in, adding 46 g sodium fluoride, reaction 140 °C reaction 5 - 8 hours, cooling to 80 °C, pressure reducing and recovering the solvent, the residue is added in dichloromethane and saturated salt water distribution, organic phase solvent, ethanol recrystallization to obtain 2 - amino 4 - fluoro pyridine, white solid, 22 g, yield 90%.
References:
Shanghai Lingkai Pharmaceutical Technology Co., Ltd.;Liang Zhujun CN108440402, 2018, A Location in patent:Paragraph 0008; 0020; 0023-0024; 0027-0028; 0031
1237535-76-0
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944401-77-8
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$17.00/1g
75279-39-9
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$167.00/250mg
944401-77-8
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34941-91-8
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944401-77-8
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$17.00/1g
98-98-6
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$5.00/10g
944401-77-8
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$17.00/1g