2-AMINO-4-METHYL-3-FURONITRILE synthesis
- Product Name:2-AMINO-4-METHYL-3-FURONITRILE
- CAS Number:5117-87-3
- Molecular formula:C6H6N2O
- Molecular Weight:122.12
Yield:5117-87-3 30%
Reaction Conditions:
with triethylamine in methanol at 0 - 20;
Steps:
66.1
To a mixture of malonontrile (0.96 g, 14.6 mmol), acetol (1.08 g, 14.6 mmol) in methanol (10 mL) at 0° C. was added, dropwise, triethylamine (2.0 mL). The reaction mixture was stirred at room temperature overnight. After removal of solvent under reduced pressure the crude solid was washed with cold isopropanol to give product as white powder (0.54 g, 30%). HPLC/MS: (M+H)+ 123.3 m/z. Retention time (LC-MS)=1.81 min. 1H NMR (CD3OD): 6.58(s, 1H,); 1.95 (s, 3H).
References:
US2004/14755,2004,A1 Location in patent:Page/Page column 18-19
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