(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE synthesis
- Product Name:(2-BROMOETHOXY)-TERT-BUTYLDIMETHYLSILANE
- CAS Number:86864-60-0
- Molecular formula:C8H19BrOSi
- Molecular Weight:239.23
18162-48-6
692 suppliers
$9.00/5g
540-51-2
257 suppliers
$17.00/5g
86864-60-0
202 suppliers
$5.00/1g
Yield:86864-60-0 100%
Reaction Conditions:
Stage #1:tert-butyldimethylsilyl chloride with 1H-imidazole in N,N-dimethyl-formamide at 20; for 0.5 h;
Stage #2:2-bromoethanol in N,N-dimethyl-formamide at 20; for 16 h;
Steps:
A11 Preparation of intermediate 33:
In a round bottom flask, TBDMSC1 (10.61 g, 70.42 mmol) and imidazole (6.23 g, 91.55 mmol) were dissolved in DMF (12.5 mL) and the solution was stirred for 30 mmat rt. Then, 2-bromoethanol (5 mL, 70.42 mmol) was added and the mixture was stirred at rt for 16 hours. The reaction mixture was partitioned between Et20 and water. The organic layer was dried over MgSO4, filtered and concentrated under vacuum to give 17 g of intermediate 33 (quant. yield, colorless oil).
References:
JANSSEN PHARMACEUTICA NV;PILATTE, Isabelle, Noëlle, Constance;QUEROLLE, Olivier, Alexis, Georges;ANGIBAUD, Patrick, René;BERTHELOT, Didier, Jean-Claude;COUPA, Sophie;DEMESTRE, Christophe, Gabriel, Marcel;MEERPOEL, Lieven;MERCEY, Guillaume, Jean, Maurice;MEVELLEC, Laurence, Anne;MEYER, Christophe;PASQUIER, Elisabeth, Thérèse, Jeanne;PONCELET, Virginie, Sophie WO2017/216293, 2017, A1 Location in patent:Page/Page column 78
102229-10-7
178 suppliers
$10.00/1g
86864-60-0
202 suppliers
$5.00/1g
288-32-4
1041 suppliers
$5.00/25g
18162-48-6
692 suppliers
$9.00/5g
540-51-2
257 suppliers
$17.00/5g
86864-60-0
202 suppliers
$5.00/1g
18162-48-6
692 suppliers
$9.00/5g
540-51-2
257 suppliers
$17.00/5g
86864-60-0
202 suppliers
$5.00/1g