2-CHLORO-5-METHOXYBENZOIC ACID synthesis
- Product Name:2-CHLORO-5-METHOXYBENZOIC ACID
- CAS Number:6280-89-3
- Molecular formula:C8H7ClO3
- Molecular Weight:186.59
56961-30-9
149 suppliers
$18.00/1g
74-88-4
352 suppliers
$15.00/10g
6280-89-3
162 suppliers
$7.00/250mg
Yield: 65%
Reaction Conditions:
with sodium hydride in DMF (N,N-dimethyl-formamide) for 16 h;
Steps:
59.A Step A.; Preparation of 2-chloro-4-methoxybenzoic acid
To a solution of 2-chloro-4-hydroxybenzoic acid hydrate (2.0 g, 12 mmol), iodomethane (2.9 mL, 46 mmol) and N,N-dimethylformamide (50 mL) was added sodium hydride (1.9 g, 46 mmol; 60% dispersion in mineral oil) in one portion. After stirring the mixture vigorously for 16 h, the reaction was quenched with water and washed with ethyl acetate. The aqueous layer was then acidified with aqueous hydrogen chloride (6N) to give a white precipitate. The mixture was filtered, washed with water, and the filter cake was dried in a vacuum oven to give the desired acid as an off-white solid (1.4 g, 65%). MS (ESI) 187.1, 189.1 (M+H)
References:
Wacker, Dean A.;Zhao, Guohua;Kwon, Chet;Varnes, Jeffrey G.;Stein, Philip D. US2005/80074, 2005, A1 Location in patent:Page/Page column 33-34
54810-63-8
40 suppliers
$26.00/100mg
6280-89-3
162 suppliers
$7.00/250mg
13334-71-9
96 suppliers
$25.00/5g
6280-89-3
162 suppliers
$7.00/250mg
124-38-9
129 suppliers
$175.00/23402
2732-80-1
169 suppliers
$11.00/1g
6280-89-3
162 suppliers
$7.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
6280-89-3
162 suppliers
$7.00/250mg