2-Methoxy-3-(trifluoromethyl)pyridine synthesis
- Product Name:2-Methoxy-3-(trifluoromethyl)pyridine
- CAS Number:121643-44-5
- Molecular formula:C7H6F3NO
- Molecular Weight:177.12
124-41-4
726 suppliers
$12.00/25g
65753-47-1
379 suppliers
$8.00/5g
121643-44-5
226 suppliers
$5.00/1g
Yield:121643-44-5 89%
Reaction Conditions:
in methanol at 20; for 48 h;
Steps:
2-methoxy-3-trifluoromethylpyridine
2-Chloro-3-trifluoromethyl-pyridine (3 g, 16.53 mmol) was dissolved in 30ml of a solution of sodium methoxide (5.4M) in methanol. The mixture was stirred at ambient temperature for 2 days. After this period of time, the reaction was taken into ice and extracted with DCM three times. The combined extract was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give 2-methoxy-3-trifluoromethyl-pyridine as a light liquid (2.7 g, 89% yield). 1 H-NMR (400 MHz, DMSO-d6, 298 K): ? ppm 3.98 (s, 3H) 7.2 (dd, 1 H) 8.1 1 (d, 1 1-1) 8.45 (d, 1 H). MS: 178.1 [M+1 ]+, Rt(1) =1 .29 min.
References:
WO2013/57711,2013,A1 Location in patent:Page/Page column 45-46
81290-20-2
418 suppliers
$13.00/1g
112197-15-6
190 suppliers
$9.00/1g
121643-44-5
226 suppliers
$5.00/1g
1628-89-3
340 suppliers
$17.97/25g
2926-30-9
290 suppliers
$11.00/5g
121643-44-5
226 suppliers
$5.00/1g
2926-29-6
308 suppliers
$6.00/5g
163105-90-6
262 suppliers
$5.00/250mg
121643-44-5
226 suppliers
$5.00/1g
67-56-1
781 suppliers
$9.00/25ml
124-41-4
726 suppliers
$12.00/25g
65753-47-1
379 suppliers
$8.00/5g
121643-44-5
226 suppliers
$5.00/1g