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ChemicalBook CAS DataBase List 2-Pyridinepropanol
2859-68-9

2-Pyridinepropanol synthesis

11synthesis methods
Information regarding the commercial production of pyripropanol in open literature is very limited. However, based on its structure as a pyridine substituted propanol, its commercial synthesis would have followed standard heteroaromatic alkylation chemistry: preparation of the substituted pyridine ring, followed by side chain construction through nucleophilic substitution or Grignard type addition to introduce the propanol moiety. The resulting alcohol would then be purified, neutralised, and dried to yield technical grade pyripropanol for formulation. This inferred route aligns with industrial practice for structurally similar pyridyl alkanol regulators.
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: tetrahydrofuran
2: 28 percent / tetrahydrofuran / -50 deg C, 30 min; -78 deg C, 30 min; 20 deg C, 30 min
3: 82 percent / hydrogen / Raney nickel / ethanol / 4 h / 20 °C / 37503 Torr

References:

Al-Arnaout, A.;Courtois, G.;Miginiac, L. [Journal of Organometallic Chemistry,1987,vol. 333,p. 139 - 154]

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