(R)-2-(tert-butoxycarbonylamino)-5-methylhexanoic acid synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: triethylamine; potassium fluoride / N,N-dimethyl-formamide / 20 h / 20 °C
2: lithium hydroxide / tetrahydrofuran / 1 h / 0 - 5 °C

References:

Hoffman, Robert L.;Kania, Robert S.;Brothers, Mary A.;Davies, Jay F.;Ferre, Rose A.;Gajiwala, Ketan S.;He, Mingying;Hogan, Robert J.;Kozminski, Kirk;Li, Lilian Y.;Lockner, Jonathan W.;Lou, Jihong;Marra, Michelle T.;Mitchell, Lennert J.;Murray, Brion W.;Nieman, James A.;Noell, Stephen;Planken, Simon P.;Rowe, Thomas;Ryan, Kevin;Smith, George J.;Solowiej, James E.;Steppan, Claire M.;Taggart, Barbara [Journal of Medicinal Chemistry,2020,vol. 63,# 21,p. 12725 - 12747]