tert-butyl 4-(4-aminophenyl)-1H-pyrazole-1-carboxylate synthesis
- Product Name:tert-butyl 4-(4-aminophenyl)-1H-pyrazole-1-carboxylate
- CAS Number:209959-26-2
- Molecular formula:C14H17N3O2
- Molecular Weight:259.3
209959-25-1
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209959-26-2
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Yield:209959-26-2 100%
Reaction Conditions:
with hydrogen;5%-palladium/activated carbon in methanol at 20; for 16 h;
Steps:
111.B
The product from part A (10 mmol) was treated with with 4-nitrobromobenzene (10 mmol) in the presence of Pd(Ph3P)4 (0.36 g, 0.3 mmol) under nitrogen at 78°C overnight, followed by workup as described above afforded the 4-pyrazolo -nitrobenzene derivative (0.95 g, 33%). Hydrogenation (0.85 g, 2.94 mmol) in MeOH (150 mL) in the presence of Pd (5% on C, 0.09 g) at r.t. for 16 hours afforded the aniline derivative (0.76 g, 100%).
References:
EP946508,2009,B1 Location in patent:Page/Page column 58
586-78-7
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552846-17-0
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209959-26-2
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114474-26-9
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24424-99-5
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114474-26-9
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209959-26-2
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