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Ethyl 4-benzyloxycarbonylamino-3-hydroxy-1-methyl-1H-pyrrole-2-carboxylate
Ethyl 4-benzyloxycarbonylamino-3-hydroxy-1-methyl-1H-pyrrole-2-carboxylate synthesis
1synthesis methods
- Product Name:Ethyl 4-benzyloxycarbonylamino-3-hydroxy-1-methyl-1H-pyrrole-2-carboxylate
- CAS Number:212184-25-3
- Molecular formula:C16H18N2O5
- Molecular Weight:318.32
Yield:212184-25-3 53%
Reaction Conditions:
Stage #1: ethyl 4-carboxy-3-hydroxy-1-methylpyrrole-2-carboxylatewith diphenyl-phosphinic acid;triethylamine in acetonitrile; for 5 h;Heating;Curtius rearrangement;
Stage #2: benzyl alcohol in acetonitrile; for 17 h;Heating;Addition;
References:
Urbach, Adam R.;Szewczyk, Jason W.;White, Sarah;Turner, James M.;Baird, Eldon E.;Dervan, Peter B. [Journal of the American Chemical Society,1999,vol. 121,# 50,p. 11621 - 11629]