tert-butyl 2-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate synthesis
- Product Name:tert-butyl 2-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate
- CAS Number:24153-01-3
- Molecular formula:C8H16ClNO2
- Molecular Weight:193.6711
67-56-1
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19615-30-6
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24153-01-3
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Yield:24153-01-3 100%
Reaction Conditions:
with thionyl chloride at 0; for 16 h;Heating / reflux;
Steps:
b
2-(1-(3,4-Dichlorophenylsulfonyl)piperidin-2-yl)acetic acid S14Piperidin-2-ylacetic acid methyl ester hydrochloride; Thionyl chloride (1.8 ml, 25.2 mmol) was added dropwise to a solution, cooled to 0° C., of piperidin-2-ylacetic acid hydrochloride (1.5 g, 8.4 mmol) in methanol (35 ml), and the mixture was heated for 16 h at gentle boiling and then cooled to room temperature. The solvent was removed azeotropically in vacuo with benzene. Yield: 1.3 g (100%)
References:
US2008/312231,2008,A1 Location in patent:Page/Page column 41
1658-42-0
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24153-01-3
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67-56-1
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$9.00/25ml
149518-50-3
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24153-01-3
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67-56-1
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19832-04-3
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24153-01-3
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16179-97-8
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24153-01-3
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