2,2-Dimethyl-N-[2-(pyridine-4-carbonyl)-phenyl]-propionamide synthesis

Yield:280568-14-1 84%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane; for 5 h;

Steps:

To a vigorously stirred solution of 72 (1.21 g, 4.03 mmol) in methylene chloride (45 mL) was added manganese oxide (5.2 g, 59.8 mmol). After 5 hours the reaction was filtered over celite and the celite washed with methylene chloride. The filtrate was concentrated to an oil and triturated with hexanes. The hexanes were removed via pipette and the solid was dried in vacuo to give a 73 (1.01 g, 84%) as a tan solid

References:

US2006/25407,2006,A1 Location in patent:Page/Page column 41