1-benzyl-6-methyl-2,4(1H,3H)-pyrimidinedione(SALTDATA: FREE) synthesis
- Product Name:1-benzyl-6-methyl-2,4(1H,3H)-pyrimidinedione(SALTDATA: FREE)
- CAS Number:33443-58-2
- Molecular formula:C12H12N2O2
- Molecular Weight:216.24
Yield:33443-58-2 76%
Reaction Conditions:
Stage #1: benzylamine;2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine at 130; for 0.5 h;Sealed tube;
Stage #2: at 160; for 3 h;
Steps:
1-Butyl-6-methyl-uracil 2a4
General procedure: Oxazine 1 (500 mg, 4 mmol) and Butylamine (580 mg, 8 mmol) are placed in a sealed vial, the mixture wasstirred in oil bath at 130 °C for a period of 30 minutes, after the cap is removed and the temperature is raised to170 °C and kept for a few hours, until the liquid has completely evaporated. The crude was purified using silicagel column chromatography with ethyl acetate/dichloromethane (20:80), to afford 2a as light yellow solid;yield: 515 mg (72%); mp 140-141 °C (Lit.4mp 132-133 °C).
References:
Trapani;Castriciano;Elemans;Nicosia;Mineo;Cordaro [Synlett,2021,vol. 32,# 17,p. 1714 - 1718] Location in patent:supporting information
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33443-58-2
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